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0PKP1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NamePKP1
DescriptionPlakophilin-1 (band-6 protein) (b6p).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0030057 desmosome (NAS)
0005882 intermediate filament (TAS)
0005634 nucleus (NAS)
0019215 intermediate filament binding (NAS)
0004871 signal transducer activity (TAS)
0030280 structural constituent of epidermis (NAS)
0007155 cell adhesion (NAS)
0007165 signal transduction (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The armadillo (Arm) repeat is an approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila melanogaster segment polarity gene armadillo involved in signal transduction through wingless. Animal Arm-repeat proteins function in various processes.ncluding intracellular signalling and cytoskeletal regulation.nd include such proteins as beta-catenin.he junctional plaque protein plakoglobin.he adenomatous polyposis coli (APC) tumour suppressor protein.nd the nuclear transport factor importin-alpha.mongst others . A subset of these proteins is conserved across eukaryotic kingdoms. In higher plants.ome Arm-repeat proteins function in intracellular signalling like their mammalian counterparts.hile others have novel functions .The 3-dimensional fold of an armadillo repeat is known from the crystal structure of beta-catenin.here the 12 repeats form a superhelix of alpha helices with three helices per unit . The cylindrical structure features a positively charged grove.hich presumably interacts with the acidic surfaces of the known interaction partners of beta-catenin.
  IPR000225:Armadillo
This domain consists of a multi-helical fold comprised of two curved layers of alpha helices arranged in a regular right-handed superhelix.here the repeats that make up this structure are arranged about a common axis . These superhelical structures present an extensive solvent-accessible surface that is well suited to binding large substrates such as proteins and nucleic acids. This topology has been found with a number of repeats and domains.ncluding the armadillo repeat (found in beta-catenins and importins).he HEAT repeat (found in protein phosphatase 2a and initiation factor eIF4G).he PHAT domain (found in Smaug RNA-binding protein).he leucine-rich repeat variant.he Pumilo repeat.nd in the H regulatory subunit of V-type ATPases. The sequence similarity among these different repeats or domains is low.owever they exhibit considerable structural similarity. Furthermore.he number of repeats present in the superhelical structure can vary between orthologues.ndicating that rapid loss/gain of repeats has occurred frequently in evolution. A common phylogenetic origin has been proposed for the armadillo and HEAT repeats .
  IPR011989:Armadillo-like helical
IPR000225:Arm 
Evalue:-10.3372421264648 
Location:276-316IPR000225:Arm 
Evalue:-3.65757727622986 
Location:536-577IPR000225:ARM 
Evalue:-3.24412514432751 
Location:318-359IPR000225:Arm 
Evalue:-1.67778074741364 
Location:583-624IPR000225:ARM 
Evalue:1.41497334797082 
Location:437-484IPR000225:ARM 
Evalue:1.51851393987789 
Location:625-670
SequencesProtein: PKP1_HUMAN (747 aa)
mRNA: NM_000299
Local Annotation
Synapse Ontology
Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).
sdb:0033 regulation of synapse structure  (Evidence:keywords)
intermediate filaments of the presynaptic compartments. Both microtubles and intermediate filaments represent the main structural scaffold of axons.
sdb:0086 intermediate filaments  (Evidence:keywords)
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 152 residues, 199519202-199519655Exon2: 36 residues, 199529692-199529796Exon3: 133 residues, 199548916-199549311Exon4: 50 residues, 199552303-199552448Exon5: 71 residues, 199553322-199553530Exon6: 61 residues, 199554368-199554546Exon7: 23 residues, 199555566-199555629Exon8: 40 residues, 199556017-199556132Exon9: 54 residues, 199557728-199557884Exon10: 61 residues, 199558763-199558940Exon11: 53 residues, 199560178-199560332Exon12: 64 residues, 199560691-199560878Exon13: 30 residues, 199561504-199561589Exon14: 37 residues, 199564512-199564619Exon15: 973 residues, 199565824-199568738Exon16: 2 residues, -Jump to PKP1_HUMAN  
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Loci Cluster (Details)Loci: 3858 199370521-199390252 ~-20K 3635(TMEM9)(-)Loci: 2579 199519202-199568738 ~-50K 3639(PKP1)(+)Loci: 3857 199205142-199259451 ~-54K 3633(KIF21B)(-)Link out to UCSC