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0PK1IP_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NamePAK1IP1
Descriptionp21-activated protein kinase-interacting protein 1 (pak1-interacting protein 1) (pak/plc-interacting protein 1) (hpip1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
WD-40 repeats (also known as WD or beta-transducin repeats) are short ~40 amino acid motifs.ften terminating in a Trp-Asp (W-D) dipeptide. WD-containing proteins have 4 to 16 repeating units.ll of which are thought to form a circularised beta-propeller structure. WD-repeat proteins are a large family found in all eukaryotes and are implicated in a variety of functions ranging from signal transduction and transcription regulation to cell cycle control and apoptosis. The underlying common function of all WD-repeat proteins is coordinating multi-protein complex assemblies.here the repeating units serve as a rigid scaffold for protein interactions. The specificity of the proteins is determined by the sequences outside the repeats themselves. Examples of such complexes are G proteins (beta subunit is a beta-propeller).AFII transcription factor.nd E3 ubiquitin ligase .
  IPR001680:WD-40 repeat
The WD40 motif is found in a multitude of eukaryotic proteins involved in a variety of cellular processes . Repeated WD40 motifs act as a site for protein-protein interaction.nd proteins containing WD40 repeats are known to serve as platforms for the assembly of protein complexes or mediators of transient interplay among other proteins. In Arabidopsis sp..everal WD40-containig proteins act as key regulators of plant-specific developmental events. WD40 repeats usually assume a 7-8 bladed beta-propeller fold.ut proteins have been found with 4 to 16 repeated units.The structures of several WD40 repeat-containing proteins have been determined.ncluding the beta-1 subunit of the signal-transducing G protein heterotrimer.he C-terminal domain of yeast Tup1.he C-terminal domain of Groucho/tle1.he Cdc4 propeller domain.he bovine Arp2/3 complex 41 kDa subunit ARPC1.nd actin interacting protein 1. The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR011046:WD40-like
IPR001680:WD40 
Evalue:-7.22184896469116 
Location:113-151IPR001680:WD40 
Evalue:-6.85387182235718 
Location:72-109IPR001680:WD40 
Evalue:-3.72124648094177 
Location:235-275IPR001680:WD40 
Evalue:-2.79588007926941 
Location:30-68IPR001680:WD40 
Evalue:0.0413926851582251 
Location:194-231
SequencesProtein: PK1IP_HUMAN (392 aa)
mRNA: NM_017906
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 39 residues, 10803173-10803288Exon2: 56 residues, 10805542-10805705Exon3: 42 residues, 10810587-10810708Exon4: 27 residues, 10810783-10810858Exon5: 19 residues, 10811623-10811676Exon6: 50 residues, 10812725-10812871Exon7: 34 residues, 10812965-10813063Exon8: 35 residues, 10815633-10815733Exon9: 43 residues, 10817171-10817295Exon10: 168 residues, 10817456-10817954Exon11: 2 residues, -Jump to PK1IP_HUMAN  
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Loci Cluster (Details)Loci: 3521 10803173-10817954 ~-15K 30310(PAK1IP1)(+)Loci: 4768 10506384-10523252 ~-17K 30300(TFAP2A)(-)Link out to UCSC