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0PISD_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NamePISD
DescriptionPhosphatidylserine decarboxylase proenzyme (ec 4.1.1.65) .
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Phosphatidylserine decarboxylase plays a pivotal role in the synthesis of phospholipid by the mitochondria. The substrate phosphatidylserine is synthesized extramitochondrially and must be translocated to the mitochondria prior to decarboxylation . Phosphatidylserine decarboxylases is responsible for conversion of phosphatidylserine to phosphatidylethanolamine and plays a central role in the biosynthesis of aminophospholipids .
  IPR003817:Phosphatidylserine decarboxylase-related
Phosphatidylserine decarboxylase is synthesized as a single chain precursor. Generation of the pyruvoyl active site from a Ser is coupled to cleavage of a Gly-Ser bond between the larger (beta) and smaller (alpha chains). It is an integral membrane protein.
  IPR005221:Phosphatidylserine decarboxylase
IPR003817:PS_Dcarbxylase 
Evalue:-31.6575775146484 
Location:165-407
SequencesProtein: PISD_HUMAN (408 aa)
mRNA: CR456540
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK01613
  Level 3 annotation:
    phosphatidylserine decarboxylase
  Level 2 annotation:
    Glycerophospholipid metabolism
    Glycine
     serine and threonine metabolism
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 148 residues, 30345379-30345822Exon2: 55 residues, 30346538-30346699Exon3: 51 residues, 30346981-30347128Exon4: 48 residues, 30347319-30347458Exon5: 81 residues, 30347634-30347871Exon6: 60 residues, 30374086-30374262Exon7: 28 residues, 30376684-30376764Exon8: 24 residues, 30388129-30388195Exon9: 2 residues, -Jump to PISD_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3309 30480068-30633000 ~-153K 24579(DEPDC5)(+)Loci: 3310 30670478-30683589 ~-13K 24585(YWHAH)(+)Loci: 4563 30345379-30388195 ~-43K 24575(PISD)(-)Link out to UCSC