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0PINK1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NamePINK1
DescriptionSerine/threonine-protein kinase pink1, mitochondrial precursor (ec 2.7.1.37) (pten-induced putative kinase protein 1) (brpk).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005739 mitochondrion (IEP)
0005524 ATP binding (IDA)
0000287 magnesium ion binding (IDA)
0004674 protein serine/threonine kinase activity (IDA)
0006468 protein amino acid phosphorylation (IDA)
0007243 protein kinase cascade (IDA)
0006950 response to stress (IDA)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Eukaryotic protein kinases are enzymesthat belong to a very extensive family of proteins which share a conserved catalytic core common withboth serine/threonine and tyrosine protein kinases. There are a number of conserved regions in thecatalytic domain of protein kinases. In the N-terminal extremity of the catalytic domain there is aglycine-rich stretch of residues in the vicinity of a lysine residue.hich has been shown to be involvedin ATP binding. In the central part of the catalytic domain there is a conserved aspartic acid residuewhich is important for the catalytic activity of the enzyme . This entry includes protein kinases from eukaryotes and viruses and may include some bacterial hits too.
  IPR000719:Protein kinase
Protein kinases () catalyze the phosphotransfer reaction fundamental to most signalling and regulatory processes in the eukaryotic cell . The catalytic subunit contains a core that is common to both serine/threonine and tyrosine protein kinases. The catalytic domain contains the nucleotide-binding site and the catalytic apparatus in an inter-lobe cleft. Structurally it shares functional and structural similarities with the ATP-grasp fold.hich is found in enzymes that catalyse the formation of an amide bond.nd with PIPK (phosphoinositol phosphate kinase). The three-dimensional fold of the protein kinase catalytic domain is similar to domains found in several other proteins. These include the catalytic domain of actin-fragmin kinase.n atypical protein kinase that regulates the F-actin capping activity in plasmodia ; the catalytic domain of phosphoinositide-3-kinase (PI3K).hich phosphorylates phosphoinositides and as such is involved in a number of fundamental cellular processes such as apoptosis.roliferation.otility and adhesion ; the catalytic domain of the MHCK/EF2 kinase.n atypical protein kinase that includes the TRP (transient channel potential) calcium-channel kinase involved in the modulation of calcium channels in eukaryotic cells in response to external signals ; choline kinase.hich catalyses the ATP-dependent phosphorylation of choline during the biosynthesis of phosphatidylcholine ; and 3.-aminoglycoside phosphotransferase type IIIa. bacterial enzyme that confers resistance to a range of aminoglycoside antibiotics .
  IPR011009:Protein kinase-like
IPR000719:Pkinase 
Evalue:-19.1366767883301 
Location:266-512IPR011009:Kinase_like 
Evalue:0 
Location:153-176IPR000719:PROTEIN_KINASE_ATP 
Evalue:0 
Location:0-0
SequencesProtein: PINK1_HUMAN (581 aa)
mRNA: NM_032409
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
activation of protein kinase C
sdb:0206 activation of protein kinase C  (Evidence:keywords)
A typical resting membrane potential for neurons varies from -65 to -90 mV. This potential represents the sum of the equilibrium potentials for each contributing ion.
sdb:0237 resting membrane potentiaion  (Evidence:keywords)
the mechanism by which the restiong potential is held.
sdb:0288 maintain membrane potential  (Evidence:keywords)
KO assignmentK05688
  Level 3 annotation:
    PTEN induced putative kinase 1
  Level 2 annotation:
    Parkinson's disease
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 161 residues, 20832534-20833015Exon2: 98 residues, 20836921-20837209Exon3: 35 residues, 20838971-20839072Exon4: 63 residues, 20843569-20843752Exon5: 56 residues, 20844639-20844803Exon6: 44 residues, 20847584-20847712Exon7: 81 residues, 20848074-20848311Exon8: 361 residues, 20849513-20850590Exon9: 2 residues, -Jump to PINK1_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3776 20863095-20917097 ~-54K 591(KIF17)(-)Loci: 2487 20832534-20850590 ~-18K 586(PINK1)(+)Link out to UCSC