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0PININ_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NamePNN
DescriptionPinin (140 kda nuclear and cell adhesion-related phosphoprotein) (domain-rich serine protein) (drs-protein) (drsp) (melanoma metastasis clone a protein) (desmosome-associated protein) (sr-like protein) (nuclear protein sdk3).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This conserved region is found at the N-terminal of the member proteins. It is located adjacent and N-terminal to the pinin/SKD/memA domain . Members of this family have very varied localisations within the eukaryotic cell. Pinin is known to localise at the desmosomes and is implicated in anchoring intermediate filaments to the desmosomal plaque . SDK2/3 is a dynamically localised nuclear protein thought to be involved in modulation of alternative pre-mRNA splicing . MemA is a tumour marker preferentially expressed in human melanoma cell lines. A common feature of the members of this family is that they may all participate in regulating protein-protein interactions .
  IPR006787:Pinin/SDK
This conserved region is located adjacent and C-terminal to a N-terminal pinin/SKD domain . Members of this family have very varied localisations within the eukaryotic cell. Pinin is known to localise at the desmosomes and is implicated in anchoring intermediate filaments to the desmosomal plaque . SDK2/3 is a dynamically localised nuclear protein thought to be involved in modulation of alternative pre-mRNA splicing . MemA is a tumour marker preferentially expressed in human melanoma cell lines. A common feature of the members of this family is that they may all participate in regulating protein-protein interactions .
  IPR006786:Pinin/SDK/memA protein
IPR006787:Pinin_SDK_N 
Evalue:-101.10237121582 
Location:1-132IPR006786:Pinin_SDK_memA 
Evalue:-98.958610534668 
Location:133-263
SequencesProtein: PININ_HUMAN (717 aa)
mRNA: NM_002687
Local Annotation
Synapse Ontology
intermediate filaments of the presynaptic compartments. Both microtubles and intermediate filaments represent the main structural scaffold of axons.
sdb:0086 intermediate filaments  (Evidence:keywords)
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 66 residues, 38714150-38714347Exon2: 26 residues, 38715032-38715104Exon3: 25 residues, 38715481-38715550Exon4: 26 residues, 38716366-38716439Exon5: 33 residues, 38716547-38716642Exon6: 27 residues, 38716795-38716871Exon7: 54 residues, 38718045-38718201Exon8: 48 residues, 38718278-38718417Exon9: 575 residues, 38719457-38721178Exon10: 2 residues, -Jump to PININ_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 2833 38714150-38721178 ~-7K 11066(PNN)(+)Loci: 2832 38653238-38675926 ~-23K 11060(SIP1)(+)Link out to UCSC