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0PICK1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NamePRKCABP
DescriptionPrkca-binding protein (protein kinase c-alpha binding protein) (protein interacting with c kinase 1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005794 Golgi apparatus (ISS)
0048471 perinuclear region (ISS)
0005886 plasma membrane (IDA)
0042734 presynaptic membrane (IDA)
0016887 ATPase activity (ISS)
0046875 ephrin receptor binding (ISS)
0051020 GTPase binding (ISS)
0035256 metabotropic glutatmate receptor binding (ISS)
0008022 protein C-terminus binding (IPI)
0005080 protein kinase C binding (ISS)
0030971 receptor tyrosine kinase binding (ISS)
0007275 development (ISS)
0043045 DNA methylation during embryonic development (NAS)
0043046 DNA methylation during gametogenesis (TAS)
0015872 dopamine transport (ISS)
0015844 monoamine transport (IDA)
0045161 neuronal ion channel clustering (TAS)
0006468 protein amino acid phosphorylation (ISS)
0051260 protein homooligomerization (ISS)
0007205 protein kinase C activation (IDA)
0043113 receptor clustering (ISS)
0050803 regulation of synapse structure and function (ISS)
0006890 retrograde transport, Golgi to ER (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Arfaptin interacts with ARF1. small GTPase involved in vesicle budding at the Golgi complex and immature secretory granules. The structure of arfaptin shows that upon binding to a small GTPase.rfaptin forms a an elongated.rescent-shaped dimer of three-helix coiled-coils . The N-terminal region of ICA69 is similar to arfaptin .
  IPR010504:Arfaptin-like
PDZ domains are found in diverse signaling proteins in bacteria.easts.lants.nsects and vertebrates . PDZ domains can occur in one or multiple copies and are nearly always found in cytoplasmic proteins. They bind either the carboxyl-terminal sequences of proteins or internal peptide sequences . In most cases.nteraction between a PDZ domain and its target is constitutive.ith a binding affinity of 1 to 10 ┬ÁM. However.gonist-dependent activation of cell surface receptors is sometimes required to promote interaction with a PDZ protein. PDZ domain proteins are frequently associated with the plasma membrane. compartment where high concentrations of phosphatidylinositol 4.-bisphosphate (PIP2) are found. Direct interaction between PIP2 and a subset of class II PDZ domains (syntenin.ASK.iam-1) has been demonstrated. PDZ domains consist of 80 to 90 amino acids comprising six beta-strands (betaA to betaF) and two alpha-helices. and B.ompactly arranged in a globular structure. Peptide binding of the ligand takes place in an elongated surface groove as an antiparallel beta-strand interacts with the betaB strand and the B helix. The structure of PDZ domains allows binding to a free carboxylate group at the end of a peptide through a carboxylate-binding loop between the betaA and betaB strands.
  IPR001478:PDZ/DHR/GLGF
IPR010504:Arfaptin 
Evalue:-131.552841186523 
Location:117-352IPR001478:PDZ 
Evalue:-12.397940008672 
Location:31-105
SequencesProtein: PICK1_HUMAN (415 aa)
mRNA: NM_012407
Local Annotation
Synapse Ontology
all
sdb:0004 Presynaptic compartment  (Evidence:keywords)
Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).
sdb:0033 regulation of synapse structure  (Evidence:keywords)
activation of protein kinase C
sdb:0206 activation of protein kinase C  (Evidence:keywords)
Na channel plays an important role in the course of action potential.
sdb:0287 Na channel  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 65 residues, 36783348-36783540Exon2: 34 residues, 36783705-36783803Exon3: 39 residues, 36785186-36785298Exon4: 45 residues, 36790954-36791083Exon5: 24 residues, 36793656-36793723Exon6: 32 residues, 36794985-36795075Exon7: 20 residues, 36796790-36796844Exon8: 23 residues, 36797634-36797697Exon9: 46 residues, 36798429-36798563Exon10: 33 residues, 36798952-36799045Exon11: 19 residues, 36799725-36799776Exon12: 50 residues, 36800259-36800404Exon13: 281 residues, 36800816-36801653Exon14: 2 residues, -Jump to PICK1_HUMAN  
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Loci Cluster (Details)Loci: 3313 36334448-36359516 ~-25K 24689(GGA1)(+)Loci: 3314 36365427-36392885 ~-27K 24693(+)Loci: 3315 36533890-36543129 ~-9K 24705(GCAT)(+)Loci: 3316 36549334-36551448 ~-2K 24707(GALR3)(+)Loci: 3317 36783348-36801653 ~-18K 24722(PRKCABP)(+)Loci: 4568 36810855-36836622 ~-26K 24725(-)Loci: 4569 37152280-37181149 ~-29K 24733(KCNJ4)(-)Loci: 4570 37209390-37232262 ~-23K 24737(DDX17)(-)Loci: 4571 37460680-37481928 ~-21K 24750(UNC84B)(-)Loci: 4567 35932191-35938299 ~-6K 24676(SSTR3)(-)Link out to UCSC