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0PIAS2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NamePIAS2
DescriptionProtein inhibitor of activated stat2 (protein inhibitor of activated stat x) (msx-interacting zinc finger protein) (miz1) (dab2-interacting protein) (dip) (androgen receptor-interacting protein 3) (arip3) (pias-ny protein).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0050681 androgen receptor binding (NAS)
0005515 protein binding (IPI)
0003713 transcription coactivator activity (NAS)
0008270 zinc ion binding (TAS)
0030521 androgen receptor signaling pathway (NAS)
0045893 positive regulation of transcription, DNA-d... (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Miz1 (Msx-interacting-zinc finger) is a zinc finger-containing protein with homology to the yeast protein.fi-1. Miz1 is a sequence specific DNA binding protein that can function as a positive-acting transcription factor. Miz1 binds to the homeobox protein Msx2.nhancing the specific DNA-binding ability of Msx2 . Other proteins containing this domain include the human pias family (protein inhibitor of activated STAT protein).
  IPR004181:Zinc finger, MIZ-type
The SAP (after SAF-A/B.cinus and PIAS) motif is a putativeDNA binding domain found in diverse nuclear proteins involved in chromosomal organization .
  IPR003034:DNA-binding SAP
IPR004181:zf-MIZ 
Evalue:-36.6777801513672 
Location:342-394IPR003034:SAP 
Evalue:-7 
Location:11-45
SequencesProtein: PIAS2_HUMAN (621 aa)
mRNA: NM_004671
Local Annotation
Synapse Ontology
A process that increases long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers.
sdb:0039 positive regulation of long-term neuronal synaptic plasticity  (Evidence:keywords)
KO assignmentK04706
  Level 3 annotation:
    protein inhibitor of activated STAT
  Level 2 annotation:
    Jak-STAT signaling pathway
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 172 residues, 42646058-42646573Exon2: 14 residues, 42649272-42649310Exon3: 48 residues, 42654893-42655033Exon4: 59 residues, 42661919-42662091Exon5: 46 residues, 42663694-42663828Exon6: 55 residues, 42670317-42670478Exon7: 26 residues, 42678014-42678088Exon8: 37 residues, 42678694-42678800Exon9: 47 residues, 42680667-42680802Exon10: 32 residues, 42689305-42689396Exon11: 19 residues, 42689525-42689576Exon12: 30 residues, 42698124-42698209Exon13: 160 residues, 42724540-42725015Exon14: 62 residues, 42751282-42751464Exon15: 2 residues, -Jump to PIAS2_HUMAN  
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