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0PIAS1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NamePIAS1
DescriptionProtein inhibitor of activated stat protein 1 (gu-binding protein) (gbp) (rna helicase ii-binding protein) (dead/h box-binding protein 1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005634 nucleus (TAS)
0050681 androgen receptor binding (NAS)
0003713 transcription coactivator activity (NAS)
0003714 transcription corepressor activity (TAS)
0030521 androgen receptor signaling pathway (NAS)
0007259 JAK-STAT cascade (TAS)
0045893 positive regulation of transcription, DNA-d... (NAS)
0007165 signal transduction (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Miz1 (Msx-interacting-zinc finger) is a zinc finger-containing protein with homology to the yeast protein.fi-1. Miz1 is a sequence specific DNA binding protein that can function as a positive-acting transcription factor. Miz1 binds to the homeobox protein Msx2.nhancing the specific DNA-binding ability of Msx2 . Other proteins containing this domain include the human pias family (protein inhibitor of activated STAT protein).
  IPR004181:Zinc finger, MIZ-type
The SAP (after SAF-A/B.cinus and PIAS) motif is a putativeDNA binding domain found in diverse nuclear proteins involved in chromosomal organization .
  IPR003034:DNA-binding SAP
IPR004181:zf-MIZ 
Evalue:-38.0268707275391 
Location:331-383IPR003034:SAP 
Evalue:-4.88605642318726 
Location:11-45
SequencesProtein: PIAS1_HUMAN (651 aa)
mRNA: NM_016166
Local Annotation
Synapse Ontology
A process that increases long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers.
sdb:0039 positive regulation of long-term neuronal synaptic plasticity  (Evidence:keywords)
KO assignmentK04706
  Level 3 annotation:
    protein inhibitor of activated STAT
  Level 2 annotation:
    Jak-STAT signaling pathway
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 40 residues, 66133625-66133742Exon2: 150 residues, 66165697-66166142Exon3: 30 residues, 66221337-66221422Exon4: 18 residues, 66221681-66221729Exon5: 32 residues, 66225207-66225298Exon6: 47 residues, 66225957-66226092Exon7: 37 residues, 66232981-66233087Exon8: 26 residues, 66244122-66244196Exon9: 55 residues, 66253123-66253284Exon10: 45 residues, 66255028-66255159Exon11: 62 residues, 66255865-66256046Exon12: 49 residues, 66260603-66260746Exon13: 14 residues, 66263021-66263059Exon14: 176 residues, 66266933-66267456Exon15: 2 residues, -Jump to PIAS1_HUMAN  
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