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0PI5PA_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NamePIB5PA
DescriptionPhosphatidylinositol 4,5-bisphosphate 5-phosphatase a (ec 3.1.3.56).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This domain is found in diverse proteins homologous to inositol monophosphatase . These proteins are Mg2+-dependent/Li+-sensitive phosphatases. That catalyse a variety of reactions.
  IPR000300:Inositol polyphosphate related phosphatase
This domain is found in a large number of proteins including magnesium dependent endonucleases and phosphatases involved in intracellular signalling . Proteins this domain is found in include: AP endonuclease proteins ().Nase I proteins ().ynaptojanin an inositol-1..-trisphosphate phosphatase () and Sphingomyelinase ().
  IPR005135:Endonuclease/exonuclease/phosphatase
IPR000300:IPPc 
Evalue:-97.8860566476932 
Location:421-736
SequencesProtein: PI5PA_HUMAN (1006 aa)
mRNA: AK092859
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentK01106
  Level 3 annotation:
    inositol-1,4,5-trisphosphate 5-phosphatase
  Level 2 annotation:
    Inositol phosphate metabolism
    Phosphatidylinositol signaling system
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 52 residues, 29848951-29849105Exon2: 390 residues, 29850830-29851996Exon3: 40 residues, 29852361-29852475Exon4: 38 residues, 29852598-29852707Exon5: 41 residues, 29852906-29853023Exon6: 60 residues, 29853342-29853518Exon7: 39 residues, 29853936-29854048Exon8: 38 residues, 29854199-29854309Exon9: 63 residues, 29854456-29854640Exon10: 48 residues, 29859083-29859221Exon11: 28 residues, 29859391-29859469Exon12: 37 residues, 29859595-29859700Exon13: 263 residues, 29859898-29860682Exon14: 2 residues, -Jump to PI5PA_HUMAN  
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