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0PI52A_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NamePIP5K2A
DescriptionPhosphatidylinositol-4-phosphate 5-kinase type ii alpha (ec 2.7.1.149) (pip5kii-alpha) (1-phosphatidylinositol-4-phosphate 5-kinase) (ptdins(4)p-5-kinase b isoform) (diphosphoinositide kinase).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The family consists of various type I.I and III phosphatidylinositol-4-phosphate 5-kinases (PIP5K enzymes). They contain a region from the common kinase core found in the typeI phosphatidylinositol-4-phosphate 5-kinase (PIP5K) family as described in. PIP5K catalyse the formation of phosphoinositol-4.-bisphosphate via the phosphorylation of phosphatidylinositol-4-phosphate a precursor in the phosphinositide signaling pathway.
  IPR002498:Phosphatidylinositol-4-phosphate 5-kinase
IPR002498:PIPKc 
Evalue:-174.45593195565 
Location:62-406
SequencesProtein: PI52A_HUMAN (406 aa)
mRNA: NM_005028
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords)
KO assignmentK00889
  Level 3 annotation:
    1-phosphatidylinositol-4-phosphate 5-kinase
  Level 2 annotation:
    Inositol phosphate metabolism
    Phosphatidylinositol signaling system
    Regulation of actin cytoskeleton
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 130 residues, 22865828-22866216Exon2: 36 residues, 22868905-22869009Exon3: 83 residues, 22870738-22870982Exon4: 40 residues, 22879593-22879707Exon5: 15 residues, 22896785-22896824Exon6: 51 residues, 22902245-22902392Exon7: 53 residues, 22920563-22920716Exon8: 34 residues, 22936861-22936958Exon9: 34 residues, 22938554-22938652Exon10: 126 residues, 23043117-23043490Exon11: 2 residues, -Jump to PI52A_HUMAN  
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