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0PEPL_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NamePPL
DescriptionPeriplakin (195 kda cornified envelope precursor protein) (190 kda paraneoplastic pemphigus antigen).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005856 cytoskeleton (TAS)
0005515 protein binding (IPI)
0005200 structural constituent of cytoskeleton (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Plectin may have a role in cross-linking intermediate filaments.n inter-linking intermediate filaments with microtubules and microfilaments and in anchoring intermediate filaments to the plasma and nuclear membranes. Plectin is recruited into hemidesmosomes multiprotein complexes that facilitate adhesion of epithelia to the basement membrane.hereby providing linkage between the intracellular keratin filaments to the laminins of the extracellular matrix. Plectin binds to hemidesmosomes through association of its actin-binding domain with the first pair of fibronectin type III repeats and a small part of the connecting segment of the integrin-beta4 subunit.he latter (integrin-alpha6.eta4) acting as a receptor for the extracellular matrix component laminin-5.The plectin repeat is also seen in the cell adhesion junction plaque proteins.esmoplakin.nvoplakin.nd bullous pemphigoid antigen. The domains in plakins show considerable sequence homology. The N-terminus consists of a plakin domain containing a number of subdomains with high alpha-helical content.hile the central coiled-coil domain is composed of heptad repeats involved in the dimerisation of plakin.nd the C-terminus contains one or more homologous repeat sequences referred to plectin repeats . This entry represents the plectin repeats found in the C-terminus of plakin proteins.
  IPR001101:Plectin repeat
Spectrin repeats are found in several proteins involved incytoskeletal structure. These include spectrin.lpha-actininand dystrophin. The spectrin repeat forms athree helix bundle. The second helix is interrupted by prolinein some sequences. The repeats are defined by a characteristictryptophan (W) residue at position 17 in helix A and a leucine(L) at 2 residues from the carboxyl end of helix C.
  IPR002017:Spectrin repeat
IPR001101:Plectin 
Evalue:-5.619788646698 
Location:1660-1692IPR001101:PLEC 
Evalue:-2.60205999132796 
Location:1700-1735IPR002017:SPEC 
Evalue:-1.10237290870956 
Location:216-317IPR002017:SPEC 
Evalue:-1.07058107428571 
Location:323-485IPR002017:SPEC 
Evalue:-0.0705810742857073 
Location:733-861IPR002017:SPEC 
Evalue:0.491361693834273 
Location:126-213IPR002017:SPEC 
Evalue:0.518513939877887 
Location:505-612
SequencesProtein: PEPL_HUMAN (1756 aa)
mRNA: NM_002705
Local Annotation
Synapse Ontology
intermediate filaments of the presynaptic compartments. Both microtubles and intermediate filaments represent the main structural scaffold of axons.
sdb:0086 intermediate filaments  (Evidence:keywords)
A dendritic spine is a mushroom-shaped bud that protrudes from a dendrite and forms one half of a synapse, especially in synapses of the cortex. The dendrites of cortical neurons typically are densely covered with such spines, which enable single cells to receive input from thousands of others.
sdb:0134 dendritic spine  (Evidence:keywords)
cytoskeleton filaments is one kind of structural components to maintain synapse morphology and bear the related function which is connected with the synaptic morphology.
sdb:0280 cytoskeletal filaments  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 1181 residues, 4872508-4876049Exon2: 33 residues, 4877136-4877229Exon3: 41 residues, 4878103-4878220Exon4: 30 residues, 4878979-4879063Exon5: 52 residues, 4880185-4880336Exon6: 66 residues, 4880729-4880923Exon7: 48 residues, 4881812-4881951Exon8: 61 residues, 4882036-4882215Exon9: 54 residues, 4883214-4883372Exon10: 34 residues, 4883542-4883640Exon11: 52 residues, 4884468-4884620Exon12: 51 residues, 4885262-4885409Exon13: 43 residues, 4885595-4885718Exon14: 34 residues, 4887676-4887772Exon15: 38 residues, 4889014-4889122Exon16: 56 residues, 4889224-4889386Exon17: 16 residues, 4890831-4890873Exon18: 44 residues, 4890965-4891091Exon19: 42 residues, 4892407-4892528Exon20: 53 residues, 4893887-4894042Exon21: 35 residues, 4900851-4900951Exon22: 52 residues, 4926985-4927137Exon23: 2 residues, -Jump to PEPL_HUMAN  
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Loci Cluster (Details)Loci: 2921 4415882-4446774 ~-31K 13438(DNAJA3)(+)Loci: 2922 4466446-4500348 ~-34K 13441(HMOX2)(+)Loci: 4208 4872508-4927137 ~-55K 13462(PPL)(-)Loci: 4207 4247192-4262891 ~-16K 13431(TFAP4)(-)Link out to UCSC