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0PE2R3_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NamePTGER3
DescriptionProstaglandin e2 receptor, ep3 subtype (prostanoid ep3 receptor) (pge receptor, ep3 subtype) (pge2-r).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (TAS)
0005635 nuclear membrane (TAS)
0005886 plasma membrane (TAS)
0004879 ligand-dependent nuclear receptor activity (TAS)
0004957 prostaglandin E receptor activity (TAS)
0008219 cell death (TAS)
0007186 G-protein coupled receptor protein signalin... (TAS)
0006351 transcription, DNA-dependent (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .Prostanoids (prostaglandins (PG) and thromboxanes (TX)) mediate a wide variety of actions and play important physiological roles in the cardiovascular and immune systems.nd in pain sensation in peripheral systems . PGI2 and TXA2 have opposing actions.nvolving regulation of the interaction of platelets with the vascular endothelium.hile PGE2.GI2 and PGD2 are powerful vasodilators and potentiate the action of various autocoids to induce plasma extravasation and pain sensation. To date.vidence for at least 5 classes of prostanoid receptor has been obtained. However.dentification of subtypes and their distribution is hampered by expression of more than one receptor within a tissue.oupled with poor selectivity of available agonists and antagonists.EP3 receptors mediate contraction in a wide range of smooth muscles.ncluding gastrointestinal and uterine. They also inhibit neurotransmitter release in central and autonomic nerves through a presynaptic action.nd inhibit secretion in glandular tissues (e.g..cid secretion fromgastric mucosa.nd sodium and water reabsorption in the kidney). mRNAis found in high levels in the kidney and uterus.nd in lower levels inthe brain.hymus.ung.eart.tomach and spleen. The receptors activateadenylate cyclase via an uncharacterised G-protein.robably of the Gi/Goclass .
  IPR000265:Prostanoid EP3 receptor
InterPro domains unassigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .
  IPR000276:Rhodopsin-like GPCR superfamily
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .Prostanoids (prostaglandins (PG) and thromboxanes (TX)) mediate a wide variety of actions and play important physiological roles in the cardiovascular and immune systems.nd in pain sensation in peripheral systems . PGI2 and TXA2 have opposing actions.nvolving regulation of the interaction of platelets with the vascular endothelium.hile PGE2.GI2 and PGD2 are powerful vasodilators and potentiate the action of various autocoids to induce plasma extravasation and pain sensation. To date.vidence for at least 5 classes of prostanoid receptor has been obtained. However.dentification of subtypes and their distribution is hampered by expression of more than one receptor within a tissue.oupled with poor selectivity of available agonists and antagonists.
  IPR001244:Prostaglandin receptor
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .Prostanoids (prostaglandins (PG) and thromboxanes (TX)) mediate a wide variety of actions and play important physiological roles in the cardiovascular and immune systems.nd in pain sensation in peripheral systems . PGI2 and TXA2 have opposing actions.nvolving regulation of the interaction of platelets with the vascular endothelium.hile PGE2.GI2 and PGD2 are powerful vasodilators and potentiate the action of various autocoids to induce plasma extravasation and pain sensation. To date.vidence for at least 5 classes of prostanoid receptor has been obtained. However.dentification of subtypes and their distribution is hampered by expression of more than one receptor within a tissue.oupled with poor selectivity of available agonists and antagonists.EP3 receptors mediate contraction in a wide range of smooth muscles.ncluding gastrointestinal and uterine . They also inhibit neurotransmitter release in central and autonomic nerves through a presynaptic action.nd inhibit secretion in glandular tissues (e.g..cid secretion fromgastric mucosa.nd sodium and water reabsorption in the kidney). mRNAis found in high levels in the kidney and uterus.nd in lower levels inthe brain.hymus.ung.eart.tomach and spleen. The receptors activateadenylate cyclase via an uncharacterised G-protein.robably of the Gi/Goclass .Sequence analysis shows the EP3 receptors to fall into distinct classes.ased on their N- and C-terminal and loop signatures. For convenience.ehave designated these classes types 1 to 3.
  IPR001481:Prostanoid EP3 receptor, type 2
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .Prostanoids (prostaglandins (PG) and thromboxanes (TX)) mediate a wide variety of actions and play important physiological roles in the cardiovascular and immune systems.nd in pain sensation in peripheral systems . PGI2 and TXA2 have opposing actions.nvolving regulation of the interaction of platelets with the vascular endothelium.hile PGE2.GI2 and PGD2 are powerful vasodilators and potentiate the action of various autocoids to induce plasma extravasation and pain sensation. To date.vidence for at least 5 classes of prostanoid receptor has been obtained. However.dentification of subtypes and their distribution is hampered by expression of more than one receptor within a tissue.oupled with poor selectivity of available agonists and antagonists.
  IPR008365:Prostanoid receptor
IPR000276:7tm_1 
Evalue:-19.1023731231689 
Location:65-346IPR001481:PRSTNOIDE32R 
Evalue:0 
Location:33-45IPR001244:PROSTAGLNDNR 
Evalue:0 
Location:53-64IPR001481:PRSTNOIDE32R 
Evalue:0 
Location:17-27IPR001481:PRSTNOIDE32R 
Evalue:0 
Location:2-12IPR000276:G_PROTEIN_RECEP_F1_1 
Evalue:0 
Location:0-0
SequencesProtein: PE2R3_HUMAN (390 aa)
mRNA: NM_198714 NM_198719
Local Annotation
Synapse Ontology
?
sdb:0219 GPCR mediated signaling  (Evidence:keywords,domains)
?
sdb:0223 transmitter release  (Evidence:keywords,domains)
all kinds of ion channels that play their roles in the synaptic activity.
sdb:0308 ion channels and receptors  (Evidence:keywords,domains)
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords,domains)
?
sdb:0328 transmitters release and endocytosis  (Evidence:keywords,domains)
KO assignmentK04260
  Level 3 annotation:
    prostaglandin E receptor 3
  Level 2 annotation:
    Calcium signaling pathway
    G-protein coupled receptors
    Neuroactive ligand-receptor interaction
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 170 residues, 71090623-71091130Exon2: 11 residues, 71192033-71192060Exon3: 32 residues, 71212567-71212659Exon4: 62 residues, 71250575-71250755Exon5: 378 residues, 71284951-71286079Exon6: 2 residues, -Jump to PE2R3_HUMANExon1: 318 residues, 71209051-71210004Exon2: 32 residues, 71212567-71212659Exon3: 62 residues, 71250575-71250755Exon4: 378 residues, 71284951-71286079Exon5: 2 residues, -Jump to PE2R3_HUMAN  
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