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0PDZK1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionPdz domain containing protein 1 (cftr associated protein of 70 kda) (na/pi cotransporter c-terminal-associated protein) (napi-cap1) (na(+)/h(+) exchanger regulatory factor 3) (sodium-hydrogen exchanger regulatory factor 3).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
PDZ domains are found in diverse signaling proteins in bacteria.easts.lants.nsects and vertebrates . PDZ domains can occur in one or multiple copies and are nearly always found in cytoplasmic proteins. They bind either the carboxyl-terminal sequences of proteins or internal peptide sequences . In most cases.nteraction between a PDZ domain and its target is constitutive.ith a binding affinity of 1 to 10 ┬ÁM. However.gonist-dependent activation of cell surface receptors is sometimes required to promote interaction with a PDZ protein. PDZ domain proteins are frequently associated with the plasma membrane. compartment where high concentrations of phosphatidylinositol 4.-bisphosphate (PIP2) are found. Direct interaction between PIP2 and a subset of class II PDZ domains (syntenin.ASK.iam-1) has been demonstrated. PDZ domains consist of 80 to 90 amino acids comprising six beta-strands (betaA to betaF) and two alpha-helices. and B.ompactly arranged in a globular structure. Peptide binding of the ligand takes place in an elongated surface groove as an antiparallel beta-strand interacts with the betaB strand and the B helix. The structure of PDZ domains allows binding to a free carboxylate group at the end of a peptide through a carboxylate-binding loop between the betaA and betaB strands.
SequencesProtein: PDZK1_HUMAN (519 aa)
mRNA: NM_002614
Local Annotation
Synapse Ontology
all the components of the clathrin coat, major ones are clathrin and clathrin adaptors.
sdb:0261 clathrin coat component  (Evidence:keywords)
Na channel plays an important role in the course of action potential.
sdb:0287 Na channel  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 9 residues, 144439082-144439106Exon2: 25 residues, 144454619-144454690Exon3: 72 residues, 144458398-144458610Exon4: 85 residues, 144459694-144459944Exon5: 47 residues, 144463784-144463921Exon6: 67 residues, 144465311-144465507Exon7: 67 residues, 144467773-144467970Exon8: 77 residues, 144472534-144472759Exon9: 99 residues, 144473395-144473686Exon10: 170 residues, 144474926-144475430Exon11: 2 residues, -Jump to PDZK1_HUMAN  
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Loci Cluster (Details)Loci: 2545 144439082-144475430 ~-36K 2379(PDZK1)(+)Loci: 3827 144297851-144300792 ~-3K 2372(NUDT17)(-)Link out to UCSC