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0PDYN_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NamePDYN
DescriptionBeta-neoendorphin-dynorphin precursor (proenkephalin b) (preprodynorphin) .
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005886 plasma membrane (IDA)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Vertebrate endogenous opioid neuropeptides are released by post-translational proteolytic cleavage of precursor proteins. The precursors consist of the following components: a signal sequence that precedes a conserved region of about 50 residues; a variable-length region; and the sequence of the neuropeptide itself. Three types of precursor are known: preproenkephalin A (gene PENK).hich is processed to produce 6 copies of Met-enkephalin.lus Leu-enkephalin; preproenkephalin B (gene PDYN).hich is processed to produce neoendorphin.ynorphin.eumorphin.imorphin and Leu-enkephalin; and prepronocipeptin (gene PNOC).hose processing produces nociceptin (orphanin FQ) and two other potential neuropeptides.Sequence analysis reveals that the conserved N-terminal region of the precursors contains 6 cysteines.hich are probably involved in disulphide bond formation. It is speculated that this region might be important for neuropeptide processing .
  IPR006024:Opioid neuropeptide precursor
Vertebrate endogenous opioid neuropeptides are released by post-translational proteolytic cleavage of precursor proteins. The precursors consist of the following components: a signal sequence that precedes a conserved region of about 50 residues; a variable-length region; and the sequence of the neuropeptide itself. Three types of precursor are known: preproenkephalin A (gene PENK).hich is processed to produce 6 copies of Met-enkephalin.lus Leu-enkephalin; preproenkephalin B (gene PDYN).hich is processed to produce neoendorphin.ynorphin.eumorphin.imorphin and Leu-enkephalin; and prepronocipeptin (gene PNOC).hose processing produces nociceptin (orphanin FQ) and two other potential neuropeptides.Sequence analysis reveals that the conserved N-terminal region of the precursors contains 6 cysteines.hich are probably involved in disulphide bond formation. It is speculated that this region might be important for neuropeptide processing .The primary structure of porcine preproenkephalin B has been elucidated andshown to contain neoendorphin.ynorphin and leumorphin (containing rimorphin as its N-terminus). These opioid peptides.ach having a Leu-enkephalin structure.ct on the kappa-receptor. The sequence similarity observed between preproenkephalin B and preproenkephalin A.oupled with the similarity between their gene organisations.uggests that the two genes have been generated from a common ancestor by gene duplication .
  IPR000750:Proenkephalin B
IPR006024:Opiods_neuropep 
Evalue:-35.8538703918457 
Location:3-69IPR000750:PENKBPRCRSR 
Evalue:0 
Location:233-251IPR000750:PENKBPRCRSR 
Evalue:0 
Location:97-114IPR000750:PENKBPRCRSR 
Evalue:0 
Location:142-155IPR000750:PENKBPRCRSR 
Evalue:0 
Location:211-224IPR006024:OPIOIDPRCRSR 
Evalue:0 
Location:170-180
SequencesProtein: PDYN_HUMAN (254 aa)
mRNA: NM_024411
Local Annotation
Synapse Ontology
?
sdb:0328 transmitters release and endocytosis  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 735 residues, 1907402-1909604Exon2: 51 residues, 1911601-1911749Exon3: 22 residues, 1921229-1921289Exon4: 50 residues, 1922556-1922702Exon5: 2 residues, -Jump to PDYN_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 4506 1907402-1922702 ~-15K 22547(PDYN)(-)Loci: 3228 1823424-1868539 ~-45K 22542(PTPNS1)(+)Link out to UCSC