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0PDP2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
Description-phosphatase 2, mitochondrial precursor (ec (pdp 2) (pyruvate dehydrogenase phosphatase, catalytic subunit 2) (pdpc 2).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This domain is found in protein phosphatase 2C.s well as other proteins eg. pyruvate dehydrogenase (lipoamide)]-phosphatase () and adenylate cyclase (). Protein phosphatase 2C (PP2C) is one of the four major classes of mammalianserine/threonine specific protein phosphatases (). PP2C is amonomeric enzyme of about 42 Kd which shows broad substrate specificity andis dependent on divalent cations (mainly manganese and magnesium) for itsactivity. Its exact physiological role is still unclear. Three isozymes arecurrently known in mammals: PP2C-alpha.beta and -gamma. In areat least four PP2C homologs: phosphatase PTC1 which has weak tyrosinephosphatase activity in addition to its activity on serines.hosphatases PTC2and PTC3.nd hypothetical protein YBR125c. Isozymes of PP2C are also knownfrom Arabidopsis thaliana (ABI1.PH1).aenorhabditis elegans (FEM-2.42G9.1.23F11.1).eishmania chagasi and Paramecium tetraurelia.In Arabidopsis thaliana.he kinase associated protein phosphatase (KAPP) is an enzyme that dephosphorylates the Ser/Thr receptor-like kinase RLK5 andwhich contains a C-terminal PP2C domain.PP2C does not seem to be evolutionary related to the main family of serine/threonine phosphatases: PP1.P2A and PP2B. However.t is significantlysimilar to the catalytic subunit of pyruvate dehydrogenase phosphatase() (PDPC) .hich catalyzes dephosphorylation and concomitantreactivation of the alpha subunit of the E1 component of the pyruvatedehydrogenase complex. PDPC is a mitochondrial enzyme and.ike PP2C.smagnesium-dependent.
  IPR001932:Protein phosphatase 2C-like
SequencesProtein: PDP2_HUMAN (529 aa)
mRNA: NM_020786
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK01102
  Level 3 annotation:
    pyruvate dehydrogenase phosphatase
  Level 2 annotation:
    Other enzymes
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 37 residues, 65471936-65472044Exon2: 1242 residues, 65475634-65479356Exon3: 2 residues, -Jump to PDP2_HUMAN  
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Loci Cluster (Details)Loci: 2945 65471936-65479356 ~-7K 14263(PDP2)(+)Loci: 4230 65513089-65516920 ~-4K 14266(RRAD)(-)Loci: 4231 65767007-65774977 ~-8K 14287(-)Loci: 2946 66153964-66230588 ~-77K 14315(CTCF)(+)Loci: 2947 66252351-66254181 ~-2K 14321(PARD6A)(+)Loci: 4232 66531287-66535516 ~-4K 14345(LCAT)(-)Loci: 4233 66535730-66560026 ~-24K 14346(SLC12A4)(-)Loci: 4229 65102150-65141816 ~-40K 14239(TK2)(-)Link out to UCSC