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0PDK1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NamePDK1
Description kinase isozyme 1, mitochondrial precursor (ec 2.7.1.99) (pyruvate dehydrogenase kinase isoform 1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005739 mitochondrion (TAS)
0004740 [pyruvate dehydrogenase (lipoamide)] kinase... (TAS)
0004672 protein kinase activity (TAS)
0006006 glucose metabolism (TAS)
0007264 small GTPase mediated signal transduction (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This domain is found in several ATP-binding proteins for example: histidine kinase.NA gyrase B.opoisomerases .eat shock protein HSP90 .hytochrome-like ATPases and DNA mismatch repair proteins.
  IPR003594:ATP-binding region, ATPase-like
IPR003594:HATPase_c 
Evalue:-21.3467884063721 
Location:268-392
SequencesProtein: PDK1_HUMAN (436 aa)
mRNA: NM_002610
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK00898
  Level 3 annotation:
    pyruvate dehydrogenase kinase
  Level 2 annotation:
    Signal transduction mechanisms
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 99 residues, 173129024-173129320Exon2: 49 residues, 173131681-173131823Exon3: 26 residues, 173135193-173135265Exon4: 63 residues, 173137476-173137661Exon5: 34 residues, 173137951-173138047Exon6: 28 residues, 173139829-173139907Exon7: 27 residues, 173141714-173141791Exon8: 35 residues, 173143699-173143798Exon9: 39 residues, 173159251-173159362Exon10: 40 residues, 173165908-173166022Exon11: 1103 residues, 173168802-173172106Exon12: 2 residues, -Jump to PDK1_HUMAN  
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Loci Cluster (Details)Loci: 3199 173308852-173625861 ~-317K 21587(RAPGEF4)(+)Loci: 3198 173129024-173172106 ~-43K 21585(PDK1)(+)Link out to UCSC