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0PDE6B_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NamePDE6B
DescriptionRod cgmp-specific 3',5'-cyclic phosphodiesterase beta-subunit (ec 3.1.4.35) (gmp-pde beta).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0004116 cGMP-specific phosphodiesterase activity (TAS)
0007603 phototransduction, visible light (TAS)
0007601 visual perception (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Retinal 3.-cGMP phosphodiesterase () (PDE) is located in photoreceptorouter segments : it is light activated.laying a pivotal role insignal transduction. In rod cells.DE is oligomeric.omprising analpha-. beta- and 2 gamma-subunits.hile in cones.DE is a homodimerof alpha chains.hich are associated with several smaller subunits.Both rod and cone PDEs catalyse the hydrolysis of cAMP or cGMP to thecorresponding nucleoside 5 monophosphates.oth enzymes also bindingcGMP with high affinity. The cGMP-binding sites are located in theN-terminal half of the protein sequence.hile the catalytic core resides in the C-terminal portion.
  IPR002073:3'5'-cyclic nucleotide phosphodiesterase
This domain is present in phytochromes and cGMP-specific phosphodiesterases. cGMP-dependent 3.-cyclic phosphodiesterase () catalyses the conversion of guanosine 3.-cyclic phosphate to guanosine 5-phosphate.A phytochrome is a regulatory photoreceptor which exists in 2 forms that are reversibly interconvertible by light.he PR form that absorbs maximally in the red region of the spectrum.nd the PFR form that absorbs maximally in the far-red region. This domain is also found in NifA. transcriptional activator which is required for activation of most Nif operons which are directly involved in nitrogen fixation. NifA interacts with sigma-54.
  IPR003018:GAF
The HD domain is found in a superfamily of enzymes with a predicted or known phosphohydrolase activity. These enzymes appear to be involved in the nucleic acid metabolism.ignal transduction and possibly other functions in bacteria.rchaea and eukaryotes.The fact that all the highly conserved redisues in the HD superfamily are histidines or aspartates suggests that coordination of divalent cations is essential for the activity of these proteins . This domain is also found in eukaryotic 3.-cGMP phosphodiesterase () (PDE).hich is located in photoreceptor outer segments and it is light activated.laying a pivotal role insignal transduction. This profile/HMM does not detect HD homologues in bacterial glycine aminoacyl-tRNA synthetases (beta subunit).
  IPR003607:Metal-dependent phosphohydrolase, HD region
IPR002073:PDEase_I 
Evalue:-139.017730712891 
Location:556-804IPR003018:GAF 
Evalue:-28.0969100130081 
Location:71-230IPR003018:GAF 
Evalue:-23.5850266520292 
Location:252-439
SequencesProtein: PDE6B_HUMAN (854 aa)
mRNA: NM_000283
Local Annotation
Synapse Ontology
Typical ecretory organelles, some 50 nm in diameter, of presynaptic nerve terminals; accumulate high concentrations of nonpeptide neurotransmitters and secrete these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
sdb:0094 typical synaptic vesicle  (Evidence:keywords)
KO assignmentK01120
  Level 3 annotation:
    3',5'-cyclic-nucleotide phosphodiesterase
  Level 2 annotation:
    Purine metabolism
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 164 residues, 609394-609883Exon2: 53 residues, 618465-618618Exon3: 32 residues, 619668-619758Exon4: 49 residues, 637640-637781Exon5: 27 residues, 637868-637943Exon6: 23 residues, 638612-638677Exon7: 24 residues, 639728-639795Exon8: 18 residues, 640033-640081Exon9: 52 residues, 640662-640812Exon10: 50 residues, 641139-641283Exon11: 24 residues, 642740-642806Exon12: 51 residues, 644255-644402Exon13: 38 residues, 645922-646030Exon14: 38 residues, 646297-646407Exon15: 31 residues, 646888-646976Exon16: 35 residues, 647558-647659Exon17: 38 residues, 647902-648010Exon18: 23 residues, 648669-648733Exon19: 27 residues, 649043-649118Exon20: 30 residues, 650319-650403Exon21: 52 residues, 651644-651795Exon22: 238 residues, 653834-654542Exon23: 2 residues, -Jump to PDE6B_HUMAN  
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Loci Cluster (Details)Loci: 4658 656225-658122 ~-2K 27158(ATP5I)(-)Loci: 4659 768745-809945 ~-41K 27171(CPLX1)(-)Loci: 4660 833065-915975 ~-83K 27175(GAK)(-)Loci: 3397 609394-654542 ~-45K 27157(PDE6B)(+)Link out to UCSC