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0PDE4B_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NamePDE4B
Descriptioncamp-specific 3',5'-cyclic phosphodiesterase 4b (ec 3.1.4.17) (dpde4) (pde32).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005626 insoluble fraction (TAS)
0005625 soluble fraction (TAS)
0004115 cAMP-specific phosphodiesterase activity (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Retinal 3.-cGMP phosphodiesterase () (PDE) is located in photoreceptorouter segments : it is light activated.laying a pivotal role insignal transduction. In rod cells.DE is oligomeric.omprising analpha-. beta- and 2 gamma-subunits.hile in cones.DE is a homodimerof alpha chains.hich are associated with several smaller subunits.Both rod and cone PDEs catalyse the hydrolysis of cAMP or cGMP to thecorresponding nucleoside 5 monophosphates.oth enzymes also bindingcGMP with high affinity. The cGMP-binding sites are located in theN-terminal half of the protein sequence.hile the catalytic core resides in the C-terminal portion.
  IPR002073:3'5'-cyclic nucleotide phosphodiesterase
The HD domain is found in a superfamily of enzymes with a predicted or known phosphohydrolase activity. These enzymes appear to be involved in the nucleic acid metabolism.ignal transduction and possibly other functions in bacteria.rchaea and eukaryotes.The fact that all the highly conserved redisues in the HD superfamily are histidines or aspartates suggests that coordination of divalent cations is essential for the activity of these proteins . This domain is also found in eukaryotic 3.-cGMP phosphodiesterase () (PDE).hich is located in photoreceptor outer segments and it is light activated.laying a pivotal role insignal transduction. This profile/HMM does not detect HD homologues in bacterial glycine aminoacyl-tRNA synthetases (beta subunit).
  IPR003607:Metal-dependent phosphohydrolase, HD region
IPR002073:PDEase_I 
Evalue:-160.795883178711 
Location:405-649
SequencesProtein: PDE4B_HUMAN (736 aa)
mRNA: NM_001037341
Local Annotation
Synapse Ontology
?
sdb:0265 cAMP mediated STP  (Evidence:keywords)
KO assignmentK01120
  Level 3 annotation:
    3',5'-cyclic-nucleotide phosphodiesterase
  Level 2 annotation:
    Purine metabolism
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 41 residues, 66030780-66030901Exon2: 39 residues, 66151515-66151627Exon3: 81 residues, 66156867-66157106Exon4: 67 residues, 66485730-66485925Exon5: 14 residues, 66495917-66495954Exon6: 25 residues, 66496063-66496134Exon7: 18 residues, 66504308-66504358Exon8: 39 residues, 66570778-66570891Exon9: 33 residues, 66593797-66593891Exon10: 61 residues, 66599885-66600064Exon11: 35 residues, 66601438-66601537Exon12: 57 residues, 66601677-66601842Exon13: 35 residues, 66603937-66604037Exon14: 53 residues, 66605966-66606121Exon15: 43 residues, 66606213-66606336Exon16: 63 residues, 66607057-66607240Exon17: 757 residues, 66610583-66612849Exon18: 2 residues, -Jump to PDE4B_HUMAN