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0PDC6I_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NamePDCD6IP
DescriptionProgrammed cell death 6-interacting protein (pdcd6-interacting protein) (alg-2 interacting protein 1) (hp95).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005829 cytosol (TAS)
0004871 signal transducer activity (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This functionally uncharacterised domain is found in a number of signal transduction proteins.
  IPR004328:BRO1
Protein kinases () catalyze the phosphotransfer reaction fundamental to most signalling and regulatory processes in the eukaryotic cell . The catalytic subunit contains a core that is common to both serine/threonine and tyrosine protein kinases. The catalytic domain contains the nucleotide-binding site and the catalytic apparatus in an inter-lobe cleft. Structurally it shares functional and structural similarities with the ATP-grasp fold.hich is found in enzymes that catalyse the formation of an amide bond.nd with PIPK (phosphoinositol phosphate kinase). The three-dimensional fold of the protein kinase catalytic domain is similar to domains found in several other proteins. These include the catalytic domain of actin-fragmin kinase.n atypical protein kinase that regulates the F-actin capping activity in plasmodia ; the catalytic domain of phosphoinositide-3-kinase (PI3K).hich phosphorylates phosphoinositides and as such is involved in a number of fundamental cellular processes such as apoptosis.roliferation.otility and adhesion ; the catalytic domain of the MHCK/EF2 kinase.n atypical protein kinase that includes the TRP (transient channel potential) calcium-channel kinase involved in the modulation of calcium channels in eukaryotic cells in response to external signals ; choline kinase.hich catalyses the ATP-dependent phosphorylation of choline during the biosynthesis of phosphatidylcholine ; and 3.-aminoglycoside phosphotransferase type IIIa. bacterial enzyme that confers resistance to a range of aminoglycoside antibiotics .
  IPR011009:Protein kinase-like
IPR004328:BRO1 
Evalue:-175.853866577148 
Location:3-382IPR011009:Kinase_like 
Evalue:0 
Location:736-823
SequencesProtein: PDC6I_HUMAN (868 aa)
mRNA: BC068454 NM_013374
Local Annotation
Synapse Ontology
endosome of the presynaptic compartment. A cellular structure that is involved in the transport of proteins in the neuron after the proteins are endocytosed from the outside to the inside of the cell.
sdb:0088 endosome  (Evidence:keywords)
?
sdb:0329 actin in synaptic vesicle cycling  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 292 residues, 33814560-33815433Exon2: 20 residues, 33828567-33828622Exon3: 25 residues, 33830054-33830124Exon4: 44 residues, 33838450-33838578Exon5: 53 residues, 33841682-33841836Exon6: 35 residues, 33842975-33843076Exon7: 41 residues, 33845348-33845465Exon8: 76 residues, 33852539-33852762Exon9: 43 residues, 33854699-33854823Exon10: 61 residues, 33858392-33858570Exon11: 39 residues, 33860607-33860719Exon12: 58 residues, 33861914-33862084Exon13: 85 residues, 33868983-33869232Exon14: 47 residues, 33870374-33870509Exon15: 33 residues, 33871661-33871756Exon16: 43 residues, 33880501-33880625Exon17: 64 residues, 33881738-33881926Exon18: 1119 residues, 33882846-33886198Exon19: 2 residues, -Jump to PDC6I_HUMANExon1: 116 residues, 33815088-33815433Exon2: 20 residues, 33828567-33828622Exon3: 25 residues, 33830054-33830124Exon4: 44 residues, 33838450-33838578Exon5: 53 residues, 33841682-33841836Exon6: 35 residues, 33842975-33843076Exon7: 46 residues, 33845333-33845465Exon8: 76 residues, 33852539-33852762Exon9: 43 residues, 33854699-33854823Exon10: 61 residues, 33858392-33858570Exon11: 39 residues, 33860607-33860719Exon12: 58 residues, 33861914-33862084Exon13: 85 residues, 33868983-33869232Exon14: 47 residues, 33870374-33870509Exon15: 33 residues, 33871661-33871756Exon16: 43 residues, 33880501-33880625Exon17: 64 residues, 33881738-33881926Exon18: 219 residues, 33882846-33883498Exon19: 2 residues, -Jump to PDC6I_HUMAN  
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Loci Cluster (Details)Loci: 3344 33814560-33886198 ~-72K 25375(PDCD6IP)(+)Loci: 4591 33512741-33734852 ~-222K 25373(CLASP2)(-)Link out to UCSC