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0PD2R_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NamePTGDR
DescriptionProstaglandin d2 receptor (prostanoid dp receptor) (pgd receptor).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0016021 integral to membrane (NAS)
0004956 prostaglandin D receptor activity (NAS)
0007186 G-protein coupled receptor protein signalin... (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .
  IPR000276:Rhodopsin-like GPCR superfamily
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .Prostanoids (prostaglandins (PG) and thromboxanes (TX)) mediate a wide variety of actions and play important physiological roles in the cardiovascular and immune systems.nd in pain sensation in peripheral systems . PGI2 and TXA2 have opposing actions.nvolving regulation of the interaction of platelets with the vascular endothelium.hile PGE2.GI2 and PGD2 are powerful vasodilators and potentiate the action of various autocoids to induce plasma extravasation and pain sensation. To date.vidence for at least 5 classes of prostanoid receptor has been obtained. However.dentification of subtypes and their distribution is hampered by expression of more than one receptor within a tissue.oupled with poor selectivity of available agonists and antagonists.DP receptors have a limited distribution. They mediate relaxation invascular.astrointestinal and uterine smooth muscle in human and someother species; they inhibit platelet activation.nd modify release ofhypothalamic and pituitary hormones. The receptors activate adenylylcyclase through G proteins .
  IPR000376:Prostaglandin D receptor
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .Prostanoids (prostaglandins (PG) and thromboxanes (TX)) mediate a widevariety of actions and play important physiological roles in the cardiovascular and immune systems.nd in pain sensation in peripheral systems. PGI2 and TXA2 have opposing actions.nvolving regulation of theinteraction of platelets with the vascular endothelium. To date.videncefor at least 5 classes of prostanoid receptor has been obtained. However.dentification of subtypes and their distribution is hampered by expressionof more than one receptor within a tissue.oupled with poor selectivity ofavailable agonists and antagonists. Moreover.any endogenous prostanoidsundergo rapid metabolism.specially TXA2 .
  IPR001105:Thromboxane receptor
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .Prostanoids (prostaglandins (PG) and thromboxanes (TX)) mediate a wide variety of actions and play important physiological roles in the cardiovascular and immune systems.nd in pain sensation in peripheral systems . PGI2 and TXA2 have opposing actions.nvolving regulation of the interaction of platelets with the vascular endothelium.hile PGE2.GI2 and PGD2 are powerful vasodilators and potentiate the action of various autocoids to induce plasma extravasation and pain sensation. To date.vidence for at least 5 classes of prostanoid receptor has been obtained. However.dentification of subtypes and their distribution is hampered by expression of more than one receptor within a tissue.oupled with poor selectivity of available agonists and antagonists.
  IPR008365:Prostanoid receptor
IPR000276:7tm_1 
Evalue:-9.79588031768799 
Location:33-323IPR000376:PRSTNOIDDPR 
Evalue:0 
Location:328-348IPR000376:PRSTNOIDDPR 
Evalue:0 
Location:6-20IPR000276:G_PROTEIN_RECEP_F1_1 
Evalue:0 
Location:0-0
SequencesProtein: PD2R_HUMAN (359 aa)
mRNA: NM_000953
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentK04332
  Level 3 annotation:
    prostaglandin D2 receptor
  Level 2 annotation:
    G-protein coupled receptors
    Neuroactive ligand-receptor interaction
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 317 residues, 51804180-51805128Exon2: 666 residues, 51811198-51813191Exon3: 2 residues, -Jump to PD2R_HUMAN  
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