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0PCDH7_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NamePCDH7
DescriptionProtocadherin 7 precursor (brain-heart protocadherin) (bh-pcdh).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (TAS)
0005886 plasma membrane (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The structure of protocadherins is similar to that of classic cadherins ().ut they also have some unique features associated with the cytoplasmic domains. They are expressed in a variety of organisms and are found in high concentrations in the brain where they seem to be localised mainly at cell-cell contact sites. Their expression seems to be developmentally regulated .
  IPR013585:Protocadherin
Cadherins are a family of adhesion molecules that mediate Ca2+-dependent cell-cell adhesion in all solid tissues of the organism which modulate a wide variety of processes including cell polarisation and migration . Cadherin-mediated cell-cell junctions are formed as a result of interaction between extracellular domains of identical cadherins.hich are located on the membranes of the neighbouring cells. The stability of these adhesive junctions is ensured by binding of the intracellular cadherin domain with the actin cytoskeleton. There are a number of different isoforms distributed in a tissue-specific manner in a wide variety of organisms. Cells containing different cadherins tend to segregate in vitro.hile those that contain the same cadherins tend to preferentially aggregate together. This observation is linked to the finding that cadherin expression causes morphological changes involving the positional segregation of cells into layers.uggesting they may play an important role in the sorting of different cell types during morphogenesis.istogenesis and regeneration. They may also be involved in the regulation of tight and gap junctions.nd in the control of intercellular spacing. Cadherins are evolutionary related to the desmogleins which are component of intercellular desmosome junctions involved in the interaction of plaque proteins.Structurally.adherins comprise a number of domains: classically.hese include a signal sequence; a propeptide of around 130 residues; a single transmembrane domain and five tandemly repeated extracellular cadherin domains. of which are cadherin repeats.nd the fifth contains 4 conserved cysteines and a N-terminal cytoplasmic domain . However.roteins are designated as members of the broadly defined cadherin family if they have one or more cadherin repeats. A cadherin repeat is an independently folding sequence of approximately 110 amino acids that contains motifs with the conserved sequences DRE.XNDNAPXF.nd DXD. Crystal structures have revealed that multiple cadherin domains form Ca2+-dependent rod-like structures with a conserved Ca2+-binding pocket at thedomain-domain interface. Cadherins depend on calcium for their function: calcium ions bind to specific residues in each cadherin repeat to ensure its proper folding.o confer rigidity upon the extracellular domain and is essential for cadherin adhesive function and for protection against protease digestion.
  IPR002126:Cadherin
This cadherin domain is usually the most N-terminal copy of cadherin domains.
  IPR013164:Cadherin-like
IPR013585:Protocadherin 
Evalue:-155.259643554687 
Location:842-1055IPR002126:CA 
Evalue:-26.1487416512809 
Location:557-637IPR002126:CA 
Evalue:-25.602059991328 
Location:661-740IPR002126:Cadherin 
Evalue:-22 
Location:313-406IPR002126:CA 
Evalue:-19.2596373105058 
Location:445-533IPR002126:CA 
Evalue:-17.9208187539524 
Location:165-306IPR002126:Cadherin 
Evalue:-16.32790184021 
Location:761-840IPR013164:Cadherin_2 
Evalue:-5.49485015869141 
Location:32-118IPR002126:CADHERIN_1 
Evalue:0 
Location:131-141
SequencesProtein: PCDH7_HUMAN (1069 aa)
mRNA: NM_002589
Local Annotation
Synapse Ontology
all
sdb:0004 Presynaptic compartment  (Evidence:keywords)
Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).
sdb:0033 regulation of synapse structure  (Evidence:keywords)
The formation of a synapse.
sdb:0034 synaptogenesis  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 1395 residues, 30331134-30335316Exon2: 156 residues, 30341472-30341936Exon3: 2 residues, -Jump to PCDH7_HUMAN  
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