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0PCDGG_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NamePCDHGB4
DescriptionProtocadherin gamma b4 precursor (pcdh-gamma-b4) (cadherin-20) (fibroblast cadherin 2).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0016020 membrane (NAS)
0016339 calcium-dependent cell-cell adhesion (NAS)
0007155 cell adhesion (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This cadherin domain is usually the most N-terminal copy of cadherin domains.
  IPR013164:Cadherin-like
Cadherins are a family of adhesion molecules that mediate Ca2+-dependent cell-cell adhesion in all solid tissues of the organism which modulate a wide variety of processes including cell polarisation and migration . Cadherin-mediated cell-cell junctions are formed as a result of interaction between extracellular domains of identical cadherins.hich are located on the membranes of the neighbouring cells. The stability of these adhesive junctions is ensured by binding of the intracellular cadherin domain with the actin cytoskeleton. There are a number of different isoforms distributed in a tissue-specific manner in a wide variety of organisms. Cells containing different cadherins tend to segregate in vitro.hile those that contain the same cadherins tend to preferentially aggregate together. This observation is linked to the finding that cadherin expression causes morphological changes involving the positional segregation of cells into layers.uggesting they may play an important role in the sorting of different cell types during morphogenesis.istogenesis and regeneration. They may also be involved in the regulation of tight and gap junctions.nd in the control of intercellular spacing. Cadherins are evolutionary related to the desmogleins which are component of intercellular desmosome junctions involved in the interaction of plaque proteins.Structurally.adherins comprise a number of domains: classically.hese include a signal sequence; a propeptide of around 130 residues; a single transmembrane domain and five tandemly repeated extracellular cadherin domains. of which are cadherin repeats.nd the fifth contains 4 conserved cysteines and a N-terminal cytoplasmic domain . However.roteins are designated as members of the broadly defined cadherin family if they have one or more cadherin repeats. A cadherin repeat is an independently folding sequence of approximately 110 amino acids that contains motifs with the conserved sequences DRE.XNDNAPXF.nd DXD. Crystal structures have revealed that multiple cadherin domains form Ca2+-dependent rod-like structures with a conserved Ca2+-binding pocket at thedomain-domain interface. Cadherins depend on calcium for their function: calcium ions bind to specific residues in each cadherin repeat to ensure its proper folding.o confer rigidity upon the extracellular domain and is essential for cadherin adhesive function and for protection against protease digestion.
  IPR002126:Cadherin
IPR013164:Cadherin_2 
Evalue:-46.1249389648438 
Location:31-112IPR002126:CA 
Evalue:-25.9586073148418 
Location:264-343IPR002126:CA 
Evalue:-23.568636235841 
Location:367-448IPR002126:CA 
Evalue:-22.0315170514461 
Location:472-558IPR002126:CA 
Evalue:-21.1739251972992 
Location:155-240IPR002126:CA 
Evalue:-7.61978875828839 
Location:589-670IPR002126:CADHERIN_1 
Evalue:0 
Location:121-131
SequencesProtein: PCDGG_HUMAN (923 aa)
mRNA: NM_003736
Local Annotation
Synapse Ontology
all
sdb:0004 Presynaptic compartment  (Evidence:keywords)
Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).
sdb:0033 regulation of synapse structure  (Evidence:keywords)
The formation of a synapse.
sdb:0034 synaptogenesis  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 808 residues, 140690435-140692856Exon2: 21 residues, 140854557-140854616Exon3: 31 residues, 140865143-140865232Exon4: 679 residues, 140870697-140872730Exon5: 2 residues, -Jump to PCDG1_HUMANExon1: 870 residues, 140698537-140701146Exon2: 21 residues, 140854557-140854616Exon3: 31 residues, 140865143-140865232Exon4: 679 residues, 140870697-140872730Exon5: 2 residues, -Jump to PCDG2_HUMANExon1: 809 residues, 140703784-140706208Exon2: 21 residues, 140854557-140854616Exon3: 31 residues, 140865143-140865232Exon4: 679 residues, 140870697-140872730Exon5: 2 residues, -Jump to PCDG3_HUMANExon1: 804 residues, 140710011-140712420Exon2: 21 residues, 140854557-140854616Exon3: 31 residues, 140865143-140865232Exon4: 679 residues, 140870697-140872730Exon5: 2 residues, -Jump to PCDGD_HUMANExon1: 808 residues, 140714951-140717372Exon2: 21 residues, 140854557-140854616Exon3: 31 residues, 140865143-140865232Exon4: 679 residues, 140870697-140872730Exon5: 2 residues, -Jump to PCDG4_HUMANExon1: 808 residues, 140719886-140722307Exon2: 21 residues, 140854557-140854616Exon3: 31 residues, 140865143-140865232Exon4: 679 residues, 140870697-140872730Exon5: 2 residues, -Jump to PCDGE_HUMANExon1: 808 residues, 140724081-140726502Exon2: 21 residues, 140854557-140854616Exon3: 31 residues, 140865143-140865232Exon4: 679 residues, 140870697-140872730Exon5: 2 residues, -Jump to PCDG5_HUMANExon1: 806 residues, 140730145-140732560Exon2: 21 residues, 140854557-140854616Exon3: 31 residues, 140865143-140865232Exon4: 679 residues, 140870697-140872730Exon5: 2 residues, -Jump to PCDGF_HUMANExon1: 809 residues, 140733834-140736258Exon2: 21 residues, 140854557-140854616Exon3: 31 residues, 140865143-140865232Exon4: 679 residues, 140870697-140872730Exon5: 2 residues, -Jump to PCDG6_HUMANExon1: 809 residues, 140742650-140745074Exon2: 21 residues, 140854557-140854616Exon3: 31 residues, 140865143-140865232Exon4: 679 residues, 140870697-140872730Exon5: 2 residues, -Jump to PCDG7_HUMANExon1: 800 residues, 140747635-140750032Exon2: 21 residues, 140854557-140854616Exon3: 31 residues, 140865143-140865232Exon4: 679 residues, 140870697-140872730Exon5: 2 residues, -Jump to PCDGG_HUMANExon1: 1108 residues, 140751666-140754988Exon2: 21 residues, 140854557-140854616Exon3: 31 residues, 140865143-140865232Exon4: 679 residues, 140870697-140872730Exon5: 2 residues, -Jump to PCDG8_HUMANExon1: 800 residues, 140757878-140760275Exon2: 21 residues, 140854557-140854616Exon3: 31 residues, 140865143-140865232Exon4: 679 residues, 140870697-140872730Exon5: 2 residues, -Jump to PCDGH_HUMANExon1: 809 residues, 140762703-140765127Exon2: 21 residues, 140854557-140854616Exon3: 31 residues, 140865143-140865232Exon4: 679 residues, 140870697-140872730Exon5: 2 residues, -Jump to PCDG9_HUMANExon1: 807 residues, 140767953-140770371Exon2: 21 residues, 140854557-140854616Exon3: 31 residues, 140865143-140865232Exon4: 679 residues, 140870697-140872730Exon5: 2 residues, -Jump to PCDGI_HUMANExon1: 813 residues, 140772926-140775362Exon2: 21 residues, 140854557-140854616Exon3: 31 residues, 140865143-140865232Exon4: 679 residues, 140870697-140872730Exon5: 2 residues, -Jump to PCDGA_HUMANExon1: 854 residues, 140777465-140780025Exon2: 21 residues, 140854557-140854616Exon3: 31 residues, 140865143-140865232Exon4: 679 residues, 140870697-140872730Exon5: 2 residues, -Jump to PCDGJ_HUMANExon1: 898 residues, 140780720-140783411Exon2: 21 residues, 140854557-140854616Exon3: 31 residues, 140865143-140865232Exon4: 679 residues, 140870697-140872730Exon5: 2 residues, -Jump to PCDGB_HUMANExon1: 865 residues, 140790341-140792934Exon2: 21 residues, 140854557-140854616Exon3: 31 residues, 140865143-140865232Exon4: 679 residues, 140870697-140872730Exon5: 2 residues, -Jump to PCDGC_HUMANExon1: 849 residues, 140835752-140838297Exon2: 21 residues, 140854557-140854616Exon3: 31 residues, 140865143-140865232Exon4: 679 residues, 140870697-140872730Exon5: 2 residues, -Jump to PCDGK_HUMANExon1: 815 residues, 140844924-140847366Exon2: 21 residues, 140854557-140854616Exon3: 31 residues, 140865143-140865232Exon4: 679 residues, 140870697-140872730Exon5: 2 residues, -Jump to PCDGL_HUMANExon1: 821 residues, 140848991-140851451Exon2: 21 residues, 140854557-140854616Exon3: 31 residues, 140865143-140865232Exon4: 679 residues, 140870697-140872730Exon5: 2 residues, -Jump to PCDGM_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3481 140051201-140059073 ~-8K 29557(HARSL)(+)Loci: 3482 140146059-140372113 ~-226K 29559(PCDHA1)(+)Loci: 3483 140411162-140413696 ~-3K 29584(PCDHB1)(+)Loci: 3484 140454420-140457146 ~-3K 29585(PCDHB2)(+)Loci: 3485 140460417-140463589 ~-3K 29586(PCDHB3)(+)Loci: 3486 140481764-140485385 ~-4K 29587(PCDHB4)(+)Loci: 3487 140494983-140497887 ~-3K 29588(PCDHB5)(+)Loci: 3488 140510022-140513050 ~-3K 29589(PCDHB6)(+)Loci: 3489 140532426-140536140 ~-4K 29592(PCDHB7)(+)Loci: 3490 140541163-140545979 ~-5K 29593(PCDHB16)(+)Loci: 3491 140552135-140555397 ~-3K 29594(PCDHB10)(+)Loci: 3492 140559531-140562801 ~-3K 29596(PCDHB11)(+)Loci: 3493 140568474-140571880 ~-3K 29597(PCDHB12)(+)Loci: 3494 140573692-140577177 ~-3K 29598(PCDHB13)(+)Loci: 3495 140583261-140586042 ~-3K 29599(PCDHB14)(+)Loci: 3496 140605330-140607983 ~-3K 29601(PCDHB15)(+)Loci: 4735 140662380-140663796 ~-1K 29602(SLC25A2)(-)Loci: 3497 140690435-140872730 ~-182K 29604(PCDHGA1)(+)Loci: 4736 140874772-140978691 ~-104K 29642(DIAPH1)(-)Loci: 4737 141013153-141041984 ~-29K 29650(CENTD3)(-)Loci: 4734 140033674-140051155 ~-17K 29556(HARS)(-)Link out to UCSC