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0PCD16_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameDCHS1
DescriptionProtocadherin 16 precursor (dachsous 1) (cadherin-19) (fibroblast cadherin 1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0016020 membrane (NAS)
0016339 calcium-dependent cell-cell adhesion (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Cadherins are a family of adhesion molecules that mediate Ca2+-dependent cell-cell adhesion in all solid tissues of the organism which modulate a wide variety of processes including cell polarisation and migration . Cadherin-mediated cell-cell junctions are formed as a result of interaction between extracellular domains of identical cadherins.hich are located on the membranes of the neighbouring cells. The stability of these adhesive junctions is ensured by binding of the intracellular cadherin domain with the actin cytoskeleton. There are a number of different isoforms distributed in a tissue-specific manner in a wide variety of organisms. Cells containing different cadherins tend to segregate in vitro.hile those that contain the same cadherins tend to preferentially aggregate together. This observation is linked to the finding that cadherin expression causes morphological changes involving the positional segregation of cells into layers.uggesting they may play an important role in the sorting of different cell types during morphogenesis.istogenesis and regeneration. They may also be involved in the regulation of tight and gap junctions.nd in the control of intercellular spacing. Cadherins are evolutionary related to the desmogleins which are component of intercellular desmosome junctions involved in the interaction of plaque proteins.Structurally.adherins comprise a number of domains: classically.hese include a signal sequence; a propeptide of around 130 residues; a single transmembrane domain and five tandemly repeated extracellular cadherin domains. of which are cadherin repeats.nd the fifth contains 4 conserved cysteines and a N-terminal cytoplasmic domain . However.roteins are designated as members of the broadly defined cadherin family if they have one or more cadherin repeats. A cadherin repeat is an independently folding sequence of approximately 110 amino acids that contains motifs with the conserved sequences DRE.XNDNAPXF.nd DXD. Crystal structures have revealed that multiple cadherin domains form Ca2+-dependent rod-like structures with a conserved Ca2+-binding pocket at thedomain-domain interface. Cadherins depend on calcium for their function: calcium ions bind to specific residues in each cadherin repeat to ensure its proper folding.o confer rigidity upon the extracellular domain and is essential for cadherin adhesive function and for protection against protease digestion.
  IPR002126:Cadherin
IPR002126:Cadherin 
Evalue:-32.9208183288574 
Location:1110-1202IPR002126:CA 
Evalue:-31.7695510786217 
Location:495-576IPR002126:Cadherin 
Evalue:-31.6575775146484 
Location:1550-1640IPR002126:Cadherin 
Evalue:-29.2218494415283 
Location:1860-1951IPR002126:CA 
Evalue:-29.1739251972992 
Location:1671-1749IPR002126:CA 
Evalue:-26.8860566476932 
Location:277-360IPR002126:CA 
Evalue:-25.3872161432803 
Location:1772-1853IPR002126:Cadherin 
Evalue:-25.017728805542 
Location:2607-2697IPR002126:CA 
Evalue:-24.0809219076239 
Location:600-683IPR002126:CA 
Evalue:-23.8239087409443 
Location:2193-2275IPR002126:Cadherin 
Evalue:-22.3010292053223 
Location:1222-1312IPR002126:CA 
Evalue:-22.267606240177 
Location:388-470IPR002126:Cadherin 
Evalue:-20.6777801513672 
Location:2711-2804IPR002126:CA 
Evalue:-20.431798275933 
Location:1458-1544IPR002126:Cadherin 
Evalue:-20.075719833374 
Location:2487-2593IPR002126:CA 
Evalue:-19.0861861476163 
Location:2398-2480IPR002126:Cadherin 
Evalue:-17.5850257873535 
Location:899-989IPR002126:Cadherin 
Evalue:-17.1487407684326 
Location:690-781IPR002126:CA 
Evalue:-15.9208187539524 
Location:2298-2374IPR002126:Cadherin 
Evalue:-15.8239088058472 
Location:1005-1096IPR002126:Cadherin 
Evalue:-15.6575775146484 
Location:2073-2162IPR002126:CA 
Evalue:-13.602059991328 
Location:165-253IPR002126:Cadherin 
Evalue:-13.0222759246826 
Location:795-885IPR002126:CA 
Evalue:-10.4202164033832 
Location:64-141IPR002126:Cadherin 
Evalue:-9.36653137207031 
Location:2818-2871IPR002126:Cadherin 
Evalue:-5.60205984115601 
Location:1983-2059IPR002126:CA 
Evalue:-5.05060999335509 
Location:1351-1434
SequencesProtein: PCD16_HUMAN (3298 aa)
mRNA: NM_003737
Local Annotation
Synapse Ontology
all
sdb:0004 Presynaptic compartment  (Evidence:keywords)
Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).
sdb:0033 regulation of synapse structure  (Evidence:keywords)
The formation of a synapse.
sdb:0034 synaptogenesis  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 1022 residues, 6599133-6602197Exon2: 48 residues, 6602536-6602675Exon3: 96 residues, 6603004-6603288Exon4: 45 residues, 6603403-6603534Exon5: 53 residues, 6603726-6603881Exon6: 72 residues, 6603975-6604187Exon7: 40 residues, 6604358-6604472Exon8: 295 residues, 6604595-6605474Exon9: 72 residues, 6606427-6606637Exon10: 44 residues, 6607258-6607384Exon11: 82 residues, 6607478-6607718Exon12: 290 residues, 6607805-6608670Exon13: 54 residues, 6608859-6609017Exon14: 34 residues, 6609117-6609214Exon15: 66 residues, 6609422-6609616Exon16: 344 residues, 6609837-6610863Exon17: 81 residues, 6611218-6611455Exon18: 79 residues, 6611595-6611827Exon19: 65 residues, 6611924-6612113Exon20: 641 residues, 6617623-6619540Exon21: 95 residues, 6633369-6633650Exon22: 2 residues, -Jump to PCD16_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3934 6599133-6633650 ~-35K 6270(DCHS1)(-)Loci: 3935 6772331-6773715 ~-1K 6274(OR6A2)(-)Loci: 3933 6590575-6597236 ~-7K 6266(CLN2)(-)Link out to UCSC