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0PARK7_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NamePARK7
DescriptionDj-1 protein (oncogene dj1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005737 cytoplasm (TAS)
0005634 nucleus (TAS)
0007265 Ras protein signal transduction (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This signature defines a diverse group of protein families which include proteins involved in RNA-protein interaction regulation.hiamine biosynthesis.as-related signal transduction.nd those with protease activity. Examples of annotation are:Catalase A.atalase IIES-1DJ-1RNA-binding protein.egulatory subunit protease IFGAM I.utative/Intracellular proteaseChaperone hchATranscriptional regulator.raC familyTHiJ/PfpI family ,
  IPR002818:ThiJ/PfpI
These sequences represent the DJ-1 clade of the so-called ThiJ/PfpI family of proteins. PfpI.epresented by .s a putative intracellular cysteine protease. DJ-1 is described as an oncogene that acts cooperatively with H-Ras . Many members of the DJ-1 clade are annotated (apparently incorrectly) as ThiJ (thiamine pyridinylase). protein of thiamine biosynthesis. However.ublished reports of ThiJ activity and identification of a ThiJ/ThiD bifunctional protein describe an unrelated locus mapping near ThiM.ather than the DJ-1 homolog of Escherichia coli. The ThiJ designation for this family may be spurious; the cited paper refers to a locus near thiD and thiM in E. coli.nlike the gene represented here. Current public annotation reflects ThiJ/ThiD bifunctional activity.pparently a property of ThiD and not of this locus.This group of proteins are classified as either DJ-1 putative peptidases or non-peptidase homologs in MEROPS peptidase family C56 (clan PC(C)).
  IPR006287:DJ-1
IPR002818:DJ-1_PfpI 
Evalue:-48.6382713317871 
Location:32-173
SequencesProtein: PARK7_HUMAN (189 aa)
mRNA: NM_007262
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK05687
  Level 3 annotation:
    Parkinson disease (autosomal recessive, early onset) 7
  Level 2 annotation:
    Parkinson's disease
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 21 residues, 7944379-7944440Exon2: 39 residues, 7945409-7945522Exon3: 36 residues, 7947970-7948072Exon4: 22 residues, 7951991-7952051Exon5: 25 residues, 7953540-7953610Exon6: 31 residues, 7960298-7960385Exon7: 129 residues, 7967540-7967923Exon8: 2 residues, -Jump to PARK7_HUMAN  
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Loci Cluster (Details)Loci: 3768 7830261-7835682 ~-5K 298(UTS2)(-)Loci: 3769 7902494-7923474 ~-21K 300(TNFRSF9)(-)Loci: 2478 7944379-7967923 ~-24K 301(PARK7)(+)Loci: 2477 7753915-7764078 ~-10K 293(VAMP3)(+)Link out to UCSC