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0PARG_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NamePARG
DescriptionPoly(adp-ribose) glycohydrolase (ec 3.2.1.143).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005737 cytoplasm (TAS)
0004649 poly(ADP-ribose) glycohydrolase activity (IDA)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Poly(ADP-ribose) glycohydrolase (PARG) is a ubiquitously expressed exo- and endoglycohydrolase which mediates oxidative and excitotoxic neuronal death .
  IPR007724:Poly glycohydrolase
IPR007724:PARG_cat 
Evalue:-225.853866577148 
Location:577-912
SequencesProtein: PARG_HUMAN (976 aa)
mRNA: NM_003631
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK07759
  Level 3 annotation:
    poly(ADP-ribose) glycohydrolase
  Level 2 annotation:
    Other enzymes
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 405 residues, 50696332-50697546Exon2: 45 residues, 50698216-50698345Exon3: 37 residues, 50710854-50710960Exon4: 38 residues, 50720001-50720110Exon5: 28 residues, 50721605-50721684Exon6: 51 residues, 50735357-50735505Exon7: 27 residues, 50739639-50739715Exon8: 22 residues, 50743372-50743433Exon9: 28 residues, 50747527-50747607Exon10: 54 residues, 50757724-50757882Exon11: 33 residues, 50763254-50763347Exon12: 27 residues, 50793968-50794043Exon13: 30 residues, 50800387-50800471Exon14: 41 residues, 50800598-50800717Exon15: 64 residues, 51031728-51031916Exon16: 331 residues, 51032806-51033793Exon17: 24 residues, 51034710-51034777Exon18: 161 residues, 51040859-51041337Exon19: 2 residues, -Jump to PARG_HUMAN