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0PAR6G_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NamePARD6G
DescriptionPartitioning defective-6 homolog gamma (par-6 gamma) (par6d).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005515 protein binding (IPI)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The Phox and Bem1p domain.s present in many eukaryotic cytoplasmic signalling proteins. The domain adopts a beta-grasp fold.imilar tothat found in ubiquitin and Ras-binding domains. A motif.ariously termed OPR.C and AID.epresents the most conserved region of the majority of PB1 domains.nd is necessary for PB1 domain function. This function is the formation of PB1 domain heterodimers.lthough not all PB1 domain pairs associate.
  IPR000270:Octicosapeptide/Phox/Bem1p
PDZ domains are found in diverse signaling proteins in bacteria.easts.lants.nsects and vertebrates . PDZ domains can occur in one or multiple copies and are nearly always found in cytoplasmic proteins. They bind either the carboxyl-terminal sequences of proteins or internal peptide sequences . In most cases.nteraction between a PDZ domain and its target is constitutive.ith a binding affinity of 1 to 10 ┬ÁM. However.gonist-dependent activation of cell surface receptors is sometimes required to promote interaction with a PDZ protein. PDZ domain proteins are frequently associated with the plasma membrane. compartment where high concentrations of phosphatidylinositol 4.-bisphosphate (PIP2) are found. Direct interaction between PIP2 and a subset of class II PDZ domains (syntenin.ASK.iam-1) has been demonstrated. PDZ domains consist of 80 to 90 amino acids comprising six beta-strands (betaA to betaF) and two alpha-helices. and B.ompactly arranged in a globular structure. Peptide binding of the ligand takes place in an elongated surface groove as an antiparallel beta-strand interacts with the betaB strand and the B helix. The structure of PDZ domains allows binding to a free carboxylate group at the end of a peptide through a carboxylate-binding loop between the betaA and betaB strands.
  IPR001478:PDZ/DHR/GLGF
IPR000270:PB1 
Evalue:-18.9208183288574 
Location:18-98IPR001478:PDZ 
Evalue:-13 
Location:168-251
SequencesProtein: PAR6G_HUMAN (376 aa)
mRNA: AB044556
Local Annotation
Synapse Ontology
activation of protein kinase C
sdb:0206 activation of protein kinase C  (Evidence:keywords)
KO assignmentK06093
  Level 3 annotation:
    par-6 partitioning defective 6 homolog (C.elegans)
  Level 2 annotation:
    Tight junction
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 279 residues, 76018644-76019480Exon2: 76 residues, 76061583-76061806Exon3: 26 residues, 76106150-76106222Exon4: 2 residues, -Jump to PAR6G_HUMAN  
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Loci Cluster (Details)Loci: 4348 76018644-76106222 ~-88K 17476(PARD6G)(-)Loci: 3075 75895345-75907375 ~-12K 17472(C18orf22)(+)Link out to UCSC