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0PAR6B_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NamePARD6B
DescriptionPartitioning defective-6 homolog beta (par-6 beta) (par-6b).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005886 plasma membrane (IDA)
0005923 tight junction (IDA)
0005515 protein binding (IPI)
0007409 axonogenesis (TAS)
0007163 establishment and/or maintenance of cell po... (TAS)
0007043 intercellular junction assembly (TAS)
0030334 regulation of cell migration (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The Phox and Bem1p domain.s present in many eukaryotic cytoplasmic signalling proteins. The domain adopts a beta-grasp fold.imilar tothat found in ubiquitin and Ras-binding domains. A motif.ariously termed OPR.C and AID.epresents the most conserved region of the majority of PB1 domains.nd is necessary for PB1 domain function. This function is the formation of PB1 domain heterodimers.lthough not all PB1 domain pairs associate.
  IPR000270:Octicosapeptide/Phox/Bem1p
PDZ domains are found in diverse signaling proteins in bacteria.easts.lants.nsects and vertebrates . PDZ domains can occur in one or multiple copies and are nearly always found in cytoplasmic proteins. They bind either the carboxyl-terminal sequences of proteins or internal peptide sequences . In most cases.nteraction between a PDZ domain and its target is constitutive.ith a binding affinity of 1 to 10 ┬ÁM. However.gonist-dependent activation of cell surface receptors is sometimes required to promote interaction with a PDZ protein. PDZ domain proteins are frequently associated with the plasma membrane. compartment where high concentrations of phosphatidylinositol 4.-bisphosphate (PIP2) are found. Direct interaction between PIP2 and a subset of class II PDZ domains (syntenin.ASK.iam-1) has been demonstrated. PDZ domains consist of 80 to 90 amino acids comprising six beta-strands (betaA to betaF) and two alpha-helices. and B.ompactly arranged in a globular structure. Peptide binding of the ligand takes place in an elongated surface groove as an antiparallel beta-strand interacts with the betaB strand and the B helix. The structure of PDZ domains allows binding to a free carboxylate group at the end of a peptide through a carboxylate-binding loop between the betaA and betaB strands.
  IPR001478:PDZ/DHR/GLGF
IPR000270:PB1 
Evalue:-20.5228786468506 
Location:16-96IPR001478:PDZ 
Evalue:-13.130768280269 
Location:167-250
SequencesProtein: PAR6B_HUMAN (372 aa)
mRNA: NM_032521
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords)
activation of protein kinase C
sdb:0206 activation of protein kinase C  (Evidence:keywords)
KO assignmentK06093
  Level 3 annotation:
    par-6 partitioning defective 6 homolog (C.elegans)
  Level 2 annotation:
    Tight junction
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 104 residues, 48781487-48781796Exon2: 76 residues, 48787800-48788023Exon3: 1362 residues, 48799602-48803684Exon4: 2 residues, -Jump to PAR6B_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3266 48781487-48803684 ~-22K 23338(PARD6B)(+)Loci: 4530 48940289-48980934 ~-41K 23342(ADNP)(-)Loci: 4531 49053600-49060282 ~-7K 23345(KCNG1)(-)Loci: 3265 48560297-48634491 ~-74K 23336(PTPN1)(+)Link out to UCSC