SynDB Home Page
SynDB Home Page
Browse
Search
Download
Help
People
links

blue bulletSynDB protein details  


Parse error: syntax error, unexpected T_VARIABLE in /home/kongl/syndb/www/sdb_nats.php on line 52
0PAR6A_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NamePARD6A
DescriptionPartitioning defective-6 homolog alpha (par-6 alpha) (par-6a) (par-6) (par6c) (tax interaction protein 40) (tip-40).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005634 nucleus (ISS)
0005923 tight junction (ISS)
0030742 GTP-dependent protein binding (ISS)
0017048 Rho GTPase binding (ISS)
0008134 transcription factor binding (TAS)
0030010 establishment of cell polarity (ISS)
0045217 intercellular junction maintenance (ISS)
0016032 viral life cycle (TAS)

Warning: fopen(/home/kongl/syndb/www/temp/1979524176.dot) [function.fopen]: failed to open stream: Permission denied in /home/kongl/syndb/www/sdb_pro.php on line 269

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 270

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 271

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 272

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 273

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 274

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 299

Warning: fclose(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 300
schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The Phox and Bem1p domain.s present in many eukaryotic cytoplasmic signalling proteins. The domain adopts a beta-grasp fold.imilar tothat found in ubiquitin and Ras-binding domains. A motif.ariously termed OPR.C and AID.epresents the most conserved region of the majority of PB1 domains.nd is necessary for PB1 domain function. This function is the formation of PB1 domain heterodimers.lthough not all PB1 domain pairs associate.
  IPR000270:Octicosapeptide/Phox/Bem1p
PDZ domains are found in diverse signaling proteins in bacteria.easts.lants.nsects and vertebrates . PDZ domains can occur in one or multiple copies and are nearly always found in cytoplasmic proteins. They bind either the carboxyl-terminal sequences of proteins or internal peptide sequences . In most cases.nteraction between a PDZ domain and its target is constitutive.ith a binding affinity of 1 to 10 ┬ÁM. However.gonist-dependent activation of cell surface receptors is sometimes required to promote interaction with a PDZ protein. PDZ domain proteins are frequently associated with the plasma membrane. compartment where high concentrations of phosphatidylinositol 4.-bisphosphate (PIP2) are found. Direct interaction between PIP2 and a subset of class II PDZ domains (syntenin.ASK.iam-1) has been demonstrated. PDZ domains consist of 80 to 90 amino acids comprising six beta-strands (betaA to betaF) and two alpha-helices. and B.ompactly arranged in a globular structure. Peptide binding of the ligand takes place in an elongated surface groove as an antiparallel beta-strand interacts with the betaB strand and the B helix. The structure of PDZ domains allows binding to a free carboxylate group at the end of a peptide through a carboxylate-binding loop between the betaA and betaB strands.
  IPR001478:PDZ/DHR/GLGF
IPR000270:PB1 
Evalue:-16.7447280883789 
Location:15-95IPR001478:PDZ 
Evalue:-11.8538719643218 
Location:167-250
SequencesProtein: PAR6A_HUMAN (346 aa)
mRNA: NM_001037281 NM_016948
Local Annotation
Synapse Ontology
activation of protein kinase C
sdb:0206 activation of protein kinase C  (Evidence:keywords)
KO assignmentK06093
  Level 3 annotation:
    par-6 partitioning defective 6 homolog (C.elegans)
  Level 2 annotation:
    Tight junction
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 52 residues, 66252351-66252505Exon2: 76 residues, 66252858-66253081Exon3: 297 residues, 66253296-66254181Exon4: 2 residues, -Jump to PAR6A_HUMANExon1: 52 residues, 66252351-66252505Exon2: 76 residues, 66252858-66253081Exon3: 296 residues, 66253299-66254181Exon4: 2 residues, -Jump to PAR6A_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 2945 65471936-65479356 ~-7K 14263(PDP2)(+)Loci: 4230 65513089-65516920 ~-4K 14266(RRAD)(-)Loci: 4231 65767007-65774977 ~-8K 14287(-)Loci: 2946 66153964-66230588 ~-77K 14315(CTCF)(+)Loci: 2947 66252351-66254181 ~-2K 14321(PARD6A)(+)Loci: 4232 66531287-66535516 ~-4K 14345(LCAT)(-)Loci: 4233 66535730-66560026 ~-24K 14346(SLC12A4)(-)Loci: 4229 65102150-65141816 ~-40K 14239(TK2)(-)Link out to UCSC