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0PANK2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NamePANK2
DescriptionPantothenate kinase 2, mitochondrial precursor (ec 2.7.1.33) (pantothenic acid kinase 2) (hpank2).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Fumble is required for cell division in Drosophila. Mutants lacking fumble exhibit abnormalities in bipolar spindle organisation.hromosome segregation.nd contractile ring formation. Analyses have demonstrated that it encodes three protein isoforms.ll of which contain a domain with high similarity to the pantothenate kinases of Emericella nidulans and mouse . A role of fumble in membrane synthesis has been proposed .
  IPR011602:Fumble
Pantothenate kinase () catalyses the conversion of CAATP and pantothenateto to ADP and D-4-phosphopantothenate.n the key regulatory step in the biosynthesis of coenzyme A (CoA) . This group describes a eukaryotic form of pantothenate kinase.haracterized from the fungus Emericella nidulans and with similar forms known in several other eukaryotes. It also includes forms from several Gram-positive bacteria suggested to have originated from the eukaryotic form by lateral transfer. It differs in a number of biochemical properties (such as inhibition by acetyl-CoA) from eubacterial PanK and shows little sequence similarity .
  IPR004567:Eukaryotic pantothenate kinase
IPR011602:Fumble 
Evalue:-220.022277832031 
Location:212-567
SequencesProtein: PANK2_HUMAN (570 aa)
mRNA: NM_153638
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords)
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 212 residues, 3817741-3818375Exon2: 119 residues, 3836572-3836925Exon3: 86 residues, 3839223-3839477Exon4: 61 residues, 3841104-3841281Exon5: 43 residues, 3845573-3845697Exon6: 44 residues, 3847317-3847443Exon7: 205 residues, 3851890-3852501Exon8: 2 residues, -Jump to PANK2_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3232 3817741-3852501 ~-35K 22637(PANK2)(+)Loci: 3233 4100356-4116369 ~-16K 22645(SMOX)(+)Loci: 3231 3724400-3734759 ~-10K 22628(CDC25B)(+)Link out to UCSC