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0PACN3_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionProtein kinase c and casein kinase substrate in neurons protein 3 (sh3 domain-containing protein 6511) (endophilin i).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005737 cytoplasm (ISS)
0008092 cytoskeletal protein binding (ISS)
0019899 enzyme binding (IPI)
0045806 negative regulation of endocytosis (ISS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This domain was first identified in cell division control protein 15 fromfission yeast where after the onset of mitosis.t forms a ring-like structurewhich co-localizes with the medial actin ring. It may mediate cytoskeletalrearrangements required for cytokinesis. Also occurs in protein-tyrosine it may play a rolein regulatory processes such as cell cycle control.nd in human Rho-GAPhematopoietic protein it has an inhibitory effect on stress fiberorganisation.
SH3 (src Homology-3) domains are small protein modules containing approximately 50 amino acid residues . They are found in a great variety of intracellular or membrane-associated proteins for example.n a variety of proteins with enzymatic activity.n adaptor proteins that lack catalytic sequences and in cytoskeletal proteins.uch as fodrin and yeast actin binding protein ABP-1. The SH3 domain has a characteristic fold which consists of five or six beta-strands arranged as two tightly packed anti-parallel beta sheets. The linker regions may contain short helices . The surface of the SH2-domain bears a flat.ydrophobic ligand-binding pocket which consists of three shallow grooves defined by conservative aromatic residues in which the ligand adopts an extended left-handed helical arrangement. The ligand binds with low affinity but this may be enhanced by multiple interactions.The region bound by the SH3 domain is in all cases proline-rich and contains PXXP as a core-conserved binding motif. The function of the SH3 domain is not well understood but they may mediate many diverse processes such as increasing local concentration of proteins.ltering their subcellular location and mediating the assembly of large multiprotein complexes .
  IPR001452:Src homology-3
In prokaryotes.he nucleotide exchange factor GrpE and the chaperone DnaJ are required for nucleotide binding of the molecular chaperone DnaK . The DnaK reaction cycle involves rapid peptide binding and release.hich is dependent upon nucleotide binding. DnaJ accelerates the hydrolysis of ATP by DnaK.hich enables the ADP-bound DnaK to tightly bind peptide. GrpE catalyses the release of ADP from DnaK.hich is required for peptide release. In eukaryotes.rpE is essential for mitochondrial Hsp70 function.owever the cytosolic Hsp70 homologues are GrpE-independent. GrpE binds as a homodimer to the ATPase domain of DnaK.nd may interact with the peptide-binding domain of DnaK. GrpE accomplishes nucleotide exchange by opening the nucleotide-binding cleft of DnaK. GrpE is comprised of two domains.he N-terminal coiled coil domain.hich may facilitate peptide release.nd the C-terminal head domain.hich forms part of the contact surface with the ATPase domain of DnaK. This entry represents the N-terminal coiled-coil domain.
  IPR013805:GrpE nucleotide exchange factor, coiled-coil
SequencesProtein: PACN3_HUMAN (424 aa)
mRNA: NM_016223
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords)
Various stages of the synaptic vesicle cycle, including attachment, prefusion, triggering, recycling and reloading of the vesicles with transmitter.
sdb:0098 synaptic vesicle cycling  (Evidence:keywords)
activation of protein kinase C
sdb:0206 activation of protein kinase C  (Evidence:keywords)
endocytosis may be initiated or blocked by all kinds of signal.
sdb:0257 regulation of endocytosis  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 172 residues, 47155660-47156173Exon2: 42 residues, 47156492-47156614Exon3: 47 residues, 47157020-47157157Exon4: 42 residues, 47157285-47157406Exon5: 60 residues, 47157537-47157713Exon6: 54 residues, 47158312-47158468Exon7: 80 residues, 47158581-47158817Exon8: 54 residues, 47160529-47160686Exon9: 32 residues, 47160800-47160891Exon10: 24 residues, 47161130-47161196Exon11: 21 residues, 47164475-47164534Exon12: 2 residues, -Jump to PACN3_HUMAN  
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Loci Cluster (Details)Loci: 3949 47415890-47427306 ~-11K 6678(RAPSN)(-)Loci: 2664 47557207-47562689 ~-5K 6687(NDUFS3)(+)Loci: 3950 47595443-47620640 ~-25K 6689(MTCH2)(-)Loci: 3948 47155660-47164534 ~-9K 6654(PACSIN3)(-)Link out to UCSC