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0PACN2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NamePACSIN2
DescriptionProtein kinase c and casein kinase substrate in neurons protein 2.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005737 cytoplasm (TAS)
0005215 transporter activity (TAS)
0030036 actin cytoskeleton organization and biogenesis (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This domain was first identified in cell division control protein 15 fromfission yeast where after the onset of mitosis.t forms a ring-like structurewhich co-localizes with the medial actin ring. It may mediate cytoskeletalrearrangements required for cytokinesis. Also occurs in protein-tyrosine kinases.here it may play a rolein regulatory processes such as cell cycle control.nd in human Rho-GAPhematopoietic protein C1.here it has an inhibitory effect on stress fiberorganisation.
  IPR001060:Cdc15/Fes/CIP4
SH3 (src Homology-3) domains are small protein modules containing approximately 50 amino acid residues . They are found in a great variety of intracellular or membrane-associated proteins for example.n a variety of proteins with enzymatic activity.n adaptor proteins that lack catalytic sequences and in cytoskeletal proteins.uch as fodrin and yeast actin binding protein ABP-1. The SH3 domain has a characteristic fold which consists of five or six beta-strands arranged as two tightly packed anti-parallel beta sheets. The linker regions may contain short helices . The surface of the SH2-domain bears a flat.ydrophobic ligand-binding pocket which consists of three shallow grooves defined by conservative aromatic residues in which the ligand adopts an extended left-handed helical arrangement. The ligand binds with low affinity but this may be enhanced by multiple interactions.The region bound by the SH3 domain is in all cases proline-rich and contains PXXP as a core-conserved binding motif. The function of the SH3 domain is not well understood but they may mediate many diverse processes such as increasing local concentration of proteins.ltering their subcellular location and mediating the assembly of large multiprotein complexes .
  IPR001452:Src homology-3
IPR001060:FCH 
Evalue:-30.3872165679932 
Location:16-104IPR001452:SH3 
Evalue:-21.3187587626244 
Location:429-486
SequencesProtein: PACN2_HUMAN (486 aa)
mRNA: NM_007229
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords)
Various stages of the synaptic vesicle cycle, including attachment, prefusion, triggering, recycling and reloading of the vesicles with transmitter.
sdb:0098 synaptic vesicle cycling  (Evidence:keywords)
activation of protein kinase C
sdb:0206 activation of protein kinase C  (Evidence:keywords)
?
sdb:0247 cytoskeleton protein transport  (Evidence:keywords)
?
sdb:0329 actin in synaptic vesicle cycling  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 567 residues, 41595721-41597419Exon2: 67 residues, 41602086-41602283Exon3: 43 residues, 41602837-41602960Exon4: 42 residues, 41604997-41605119Exon5: 42 residues, 41608133-41608254Exon6: 60 residues, 41610335-41610511Exon7: 54 residues, 41614592-41614748Exon8: 80 residues, 41616896-41617132Exon9: 54 residues, 41619406-41619563Exon10: 47 residues, 41637970-41638107Exon11: 43 residues, 41740970-41741095Exon12: 2 residues, -Jump to PACN2_HUMAN  
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Loci Cluster (Details)Loci: 4575 41595721-41741095 ~-145K 24901(PACSIN2)(-)Loci: 4576 41765589-41815373 ~-50K 24903(TTLL1)(-)Loci: 3322 41877478-41889191 ~-12K 24908(BZRP)(+)Loci: 4574 41344764-41375349 ~-31K 24894(CYB5R3)(-)Link out to UCSC