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0PACA_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameADCYAP1
DescriptionPituitary adenylate cyclase activating polypeptide precursor (pacap) .
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005625 soluble fraction (TAS)
0005184 neuropeptide hormone activity (TAS)
0007190 adenylate cyclase activation (TAS)
0007267 cell-cell signaling (TAS)
0007565 pregnancy (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
A number of polypeptidic hormones.ainly expressed in the intestine or the pancreas.elong to a group of structurally related peptides . Once such hormone.lucagon is widely distributed and produced in the alpha-cells of pancreatic islets . It affects glucose metabolism in the liver by inhibiting glycogen synthesis.timulating glycogenolysis and enchancing gluconeogenesis. It also increases mobilisation of glucose.ree fatty acids and ketone bodies.hich are metabolites produced in excess in diabetes mellitus. Glucagon is produced.ike other peptide hormones.s part of a larger precursor (preproglucagon).hich is cleaved to produce glucagon.lucagon-like protein I and glucagon-like protein II . The structure of glucagon itself is fully conserved in all known mammalian species . Other members of the structurally similar group include glicentin precursor.ecretin.astric inhibitory protein.asoactive intestinal peptide (VIP).realbumin.eptide HI-27 and growth hormone releasing factor.
  IPR000532:Glucagon/GIP/secretin/VIP
IPR000532:Hormone_2 
Evalue:-11.4202165603638 
Location:132-159IPR000532:Hormone_2 
Evalue:-7.15490198135376 
Location:83-110
SequencesProtein: PACA_HUMAN (176 aa)
mRNA: BC101803
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 61 residues, 895316-895497Exon2: 46 residues, 897659-897791Exon3: 35 residues, 898265-898364Exon4: 80 residues, 899446-899680Exon5: 2 residues, -Jump to PACA_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3052 895316-899680 ~-4K 16989(ADCYAP1)(+)Loci: 3051 570368-571524 ~-1K 16976(CETN1)(+)Link out to UCSC