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0PABP2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NamePABPN1
DescriptionPolyadenylate-binding protein 2 (poly(a)-binding protein 2) (polya binding protein ii) (pabii) (polyadenylate-binding nuclear protein 1) (nuclear poly(a)-binding protein 1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0003723 RNA binding (TAS)
0006936 muscle contraction (TAS)
0006396 RNA processing (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Many eukaryotic proteins that are known or supposed to bind single-stranded RNA contain one or more copies of a putative RNA-binding domain of about 90 amino acids. This is known as the eukaryotic putative RNA-binding region RNP-1 signature or RNA recognition motif (RRM). RRMs are found in a variety of RNA binding proteins.ncluding heterogeneous nuclear ribonucleoproteins (hnRNPs).roteins implicated in regulation of alternative splicing.nd protein components of small nuclear ribonucleoproteins (snRNPs). The RRM in heterodimeric splicing factor U2 snRNP auxiliary factor (U2AF) appears to have two RRM-like domains with specialized features for protein recognition . The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich.ith a third helix present during RNA binding in some cases .
  IPR000504:RNA-binding region RNP-1 (RNA recognition motif)
This entry represents nucleotide-binding domains with an alpha-beta plait structure.hich consists of either a ferredoxin-like (beta-alpha-beta)2 fold.uch as that found in RNA-binding domains of various ribonucleoproteins or in viral DNA-binding domains . or a beta-(alpha)-beta-alpha-beta(2) fold.uch as that found in the ribosomal protein L23 .
  IPR012677:Nucleotide-binding, alpha-beta plait
IPR000504:RRM_1 
Evalue:-18.8538722991943 
Location:173-243
SequencesProtein: PABP2_HUMAN (305 aa)
mRNA: NM_004643
Local Annotation
Synapse Ontology
Microglias, one kind of glias in CNS, are responsible for removing most of the waste and cellular debris from the CNS
sdb:0267 removing metabolic mass  (Evidence:keywords)
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 545 residues, 22859236-22860869Exon2: 40 residues, 22861229-22861344Exon3: 24 residues, 22862047-22862115Exon4: 37 residues, 22862425-22862532Exon5: 31 residues, 22863013-22863101Exon6: 52 residues, 22863186-22863338Exon7: 304 residues, 22864295-22865202Exon8: 2 residues, -Jump to PABP2_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 4116 22525950-22549192 ~-23K 10843(C14orf93)(-)Loci: 4117 22597615-22634663 ~-37K 10853(ACIN1)(-)Loci: 2824 22845875-22850798 ~-5K 10860(BCL2L2)(+)Loci: 2825 22859236-22865202 ~-6K 10861(PABPN1)(+)Loci: 4118 22895451-22904682 ~-9K 10864(EFS)(-)Loci: 4119 22921038-22947324 ~-26K 10871(MYH6)(-)Loci: 4120 22951789-22973312 ~-22K 10872(MYH7)(-)Loci: 4121 23059904-23065839 ~-6K 10876(ZFHX2)(-)Loci: 4122 23098616-23107119 ~-9K 10881(AP1G2)(-)Loci: 4115 22439745-22458214 ~-18K 10832(RBM23)(-)Link out to UCSC