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1P91954_LUCCU*   Trembl (?) | Description Local Annotation Link Reference
General Information
NameN/A
DescriptionAcetylcholinesterase.
SpeciesLucilia cuprina (NCBI taxonomy ID: 7375)
GO0045202 synapse (IEA)
0003990 acetylcholinesterase activity (IEA)
0004104 cholinesterase activity (IEA)
0016787 hydrolase activity (IEA)
0004759 serine esterase activity (IEA)
0001507 acetylcholine catabolism in synaptic cleft (IEA)
0042135 neurotransmitter catabolism (IEA)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
Group B carboxylesterases constitute a family of enzymes that includes proteins that catalyse the conversion of an acylcholine to a choline and a weak acid:Acylcholine + H2O -> Choline + COO-and those that catalyse the hydrolysis of acetylcholine to choline and acetate (acetylcholinesterases):Acetylcholine + H2O -> Choline + Acetate Acetylcholinesterase also acts on a variety of acetic esters and catalyses transacetylations. It is found in.r attached to.ellular or basement membranes of presynaptic cholinergic neurons and postsynaptic cholinoceptive cells. To prevent continuous firing of nerve impulses.cetylcholinesterase has a high K(cat) (~14000/s).o ensure that acetylcholine is broken down quickly. Cholinesterases themselves constitute a family of enzymes that fall into two main types.epending on their substrate preference; enzymes that preferentially hydrolyse acetyl esters are termed acetylcholinesterase (AChE) (); and those that prefer other types of ester.uch as butyrylcholine are termed butyrylcholinesterase (BChE) (). The 3D structure of acetylcholinesterase from Torpedo californica (Pacific Electric Ray) has been determined . The fold belongs to the alpha/beta class.ith a 3-layer alpha-beta-alpha sandwich architecture.Some of the proteins in this group are responsible for the molecular basis of the blood group antigens.urface markers on the outside of the red blood cell membrane. Most of these markers are proteins.ut some are carbohydrates attached to lipids or proteins [Reid M.E..omas-Francis C. The Blood Group Antigen FactsBook Academic Press.ondon / San Diego.1997)]. Acetylcholinesterase () belongs to the Yt blood group system and is associated with Yt(a/b) antigen.
  IPR000997:Cholinesterase
Group B carboxylesterases constitute a family of enzymes that includes proteins that catalyse the conversion of an acylcholine to a choline and a weak acid:Acylcholine + H2O -> Choline + COO-and those that catalyse the hydrolysis of acetylcholine to choline and acetate (acetylcholinesterases):Acetylcholine + H2O -> Choline + Acetate Acetylcholinesterase also acts on a variety of acetic esters and catalyses transacetylations. It is found in.r attached to.ellular or basement membranes of presynaptic cholinergic neurons and postsynaptic cholinoceptive cells. To prevent continuous firing of nerve impulses.cetylcholinesterase has a high K(cat) (~14000/s).o ensure that acetylcholine is broken down quickly. Cholinesterases themselves constitute a family of enzymes that fall into two main types.epending on their substrate preference; enzymes that preferentially hydrolyse acetyl esters are termed acetylcholinesterase (AChE) (); and those that prefer other types of ester.uch as butyrylcholine are termed butyrylcholinesterase (BChE) (). The 3D structure of acetylcholinesterase from Torpedo californica (Pacific Electric Ray) has been determined . The fold belongs to the alpha/beta class.ith a 3-layer alpha-beta-alpha sandwich architecture. Insect acetylcholinesterase is often targeted by insecticides.specially in the effort to eradicate mosquitos from certain areas of the world .
  IPR001445:Insect acetylcholinesterase
InterPro domains unassigned to SynO:
Higher eukaryotes have many distinct esterases. Among the different types arethose which act on carboxylic esters (). Carboxyl-esterases havebeen classified into three categories (A. and C) on the basis ofdifferential patterns of inhibition by organophosphates. The sequence of anumber of type-B carboxylesterases indicates that the majority are evolutionary related. As is the case for lipases and serine proteases.he catalytic apparatus ofesterases involves three residues (catalytic triad): a serine. glutamate oraspartate and a histidine.
  IPR002018:Carboxylesterase, type B
IPR002018:COesterase 
Evalue:-210.356552124023 
Location:79-657
SequencesProtein: P91954_LUCCU (708 aa)
mRNA: No corresponding mRNA found
Local Annotation
Synapse Ontology
the plasma membrane of the postsynaptic neuron. It apposes with presynaptic actiove zone.
sdb:0108 postsynaptic plasma membrane  (Evidence:keywords,domains)
transmitter inactivated by its enzyme etc.
sdb:0141 extracellular metabolism  (Evidence:keywords,domains)
?
sdb:0328 transmitters release and endocytosis  (Evidence:keywords,domains)
KO assignmentK01049
  Level 3 annotation:
    acetylcholinesterase
  Level 2 annotation:
    Glycerophospholipid metabolism
Family_id: 11 Liver carboxylesterase 1 precursor (EC 3.1.1.1) (Acyl coenzyme A:cholesterol acyltransferase) (ACAT) (Monocyte/macrophage serine esterase) (HMSE) (Serine esterase 1) (Brain carboxylesterase hBr1) (Triacylglycerol hydrolase) (TGH) (Egasyn). 
Cross Links
Ensembl familyNot mapped to Ensembl families
Protein InteractionNot mapped to Bind and PPID
PDB1LLFA: Chain A, Cholesterol Esterase (Candida Cylindracea) Crystal Structure At 1.4a Resolution
ModBaseLink out to the theoretical structure model
OMIMNot mapped to OMIM
PTMLink out to dbPTM
Gene-centric linksGEO: Expression
dbSNP: Signle Nucleotide Polymorphism
Reference
1Insect Biochem. Mol. Biol. 31:805-816(2001) The acetylcholinesterase gene and organophosphorus resistance in the Australian sheep blowfly, Lucilia cuprina.

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