SynDB Home Page
SynDB Home Page
Browse
Search
Download
Help
People
links

blue bulletSynDB protein details  


Parse error: syntax error, unexpected T_VARIABLE in /home/kongl/syndb/www/sdb_nats.php on line 52
0P5CS_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameALDH18A1
DescriptionDelta 1-pyrroline-5-carboxylate synthetase (p5cs) (aldehyde dehydrogenase 18 family member a1) .
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0006561 proline biosynthesis (TAS)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Gamma-glutamyl phosphate reductase () (GPR) is the enzyme that catalyzes the second step in the biosynthesis of proline from glutamate.he NADP-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. In bacteria (gene proA) and yeast (gene PRO2).PR is a monofunctional protein.hile in plants and mammals.t is a bifunctional enzyme (P5CS) that consists of two domains.n N-terminal glutamate 5-kinase domain () and a C-terminal GPR domain.
  IPR000965:Gamma-glutamyl phosphate reductase GPR
This entry contains proteins with various specificities and includes the aspartate.lutamate and uridylate kinase families. In prokaryotes and plants the synthesis of the essential amino acids lysine and threonine is predominantly regulated by feed-back inhibition of aspartate kinase (AK) and dihydrodipicolinate synthase (DHPS).In Escherichia coli.hrA.etLM.nd lysC encode aspartokinase isozymes that show feedback inhibition by threonine.ethionine.nd lysine.espectively . The lysine-sensitive isoenzyme of aspartate kinase from spinach leaves has a subunit composition of 4 large and 4 small subunits . In plants although the control of carbon fixation and nitrogen assimilation has been studied in detail.elatively little is known about the regulation of carbon and nitrogen flow into amino acids. The metabolic regulation of expression of an Arabidopsis thaliana aspartate kinase/homoserine dehydrogenase (AK/HSD) gene.hich encodes two linked key enzymes in the biosynthetic pathway of aspartate family amino acids has been studied . The conversion of aspartate into either the storage amino acid asparagine or aspartate family amino acids may be subject to a coordinated.eciprocal metabolic control.nd this biochemical branch point is a part of a larger.oordinated regulatory mechanism of nitrogen and carbon storage and utilization.
  IPR001048:Aspartate/glutamate/uridylate kinase
Synonym(s): Gamma-glutamyl kinaseGlutamate 5-kinase () catalyses the first stepin the biosynthesis of proline.he ATP-dependent phosphorylation of glutamate toglutamate 5-phosphate . It belongs to the larger family of aspartokinases.
  IPR001057:Glutamate 5-kinase
L-glutamate 5-phosphotransferase.gamma-glutamyl kinase.roB..atalyzes the first step in proline biosynthesis ATP + L-glutamate = ADP + L-glutamate 5-phosphate.the product of which rapidly cyclises to 5-oxoproline and phosphate. Bacterial ProB proteins hits the full length of this model.ut the ProB-like domain of delta 1-pyrroline-5-carboxylate synthetase does not hit the C-terminal 100 residues.
  IPR005715:Glutamate 5-kinase, ProB-related
delta l-pyrroline-5-carboxylate synthetase contains a glutamate 5-kinase (ProB. region followed by a gamma-glutamyl phosphate reductase (ProA. region and catalyses the first and second steps in proline biosynthesis.
  IPR005766:delta l-pyrroline-5-carboxylate synthetase
IPR001048:AA_kinase 
Evalue:-56.0555191040039 
Location:71-329IPR000965:proA 
Evalue:0 
Location:370-761
SequencesProtein: P5CS_HUMAN (795 aa)
mRNA: NM_001017423 NM_002860
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK00147
  Level 3 annotation:
    glutamate-5-semialdehyde dehydrogenase
  Level 2 annotation:
    Urea cycle and metabolism of amino groups
K00931
  Level 3 annotation:
    glutamate 5-kinase
  Level 2 annotation:
    Urea cycle and metabolism of amino groups
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 339 residues, 97355676-97356690Exon2: 34 residues, 97359943-97360039Exon3: 64 residues, 97361002-97361189Exon4: 42 residues, 97363488-97363610Exon5: 67 residues, 97363712-97363908Exon6: 48 residues, 97366223-97366361Exon7: 75 residues, 97370777-97370998Exon8: 33 residues, 97375108-97375202Exon9: 26 residues, 97376449-97376523Exon10: 50 residues, 97377188-97377333Exon11: 43 residues, 97378114-97378239Exon12: 32 residues, 97382705-97382796Exon13: 55 residues, 97383237-97383396Exon14: 37 residues, 97386839-97386944Exon15: 52 residues, 97387033-97387183Exon16: 73 residues, 97392738-97392953Exon17: 40 residues, 97403036-97403152Exon18: 73 residues, 97406343-97406557Exon19: 2 residues, -Jump to P5CS_HUMANExon1: 339 residues, 97355676-97356690Exon2: 34 residues, 97359943-97360039Exon3: 64 residues, 97361002-97361189Exon4: 42 residues, 97363488-97363610Exon5: 67 residues, 97363712-97363908Exon6: 48 residues, 97366223-97366361Exon7: 75 residues, 97370777-97370998Exon8: 33 residues, 97375108-97375202Exon9: 26 residues, 97376449-97376523Exon10: 50 residues, 97377188-97377333Exon11: 43 residues, 97378114-97378239Exon12: 32 residues, 97382705-97382796Exon13: 53 residues, 97383243-97383396Exon14: 37 residues, 97386839-97386944Exon15: 52 residues, 97387033-97387183Exon16: 73 residues, 97392738-97392953Exon17: 40 residues, 97403036-97403152Exon18: 73 residues, 97406343-97406557Exon19: 2 residues, -Jump to P5CS_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3911 97355676-97406557 ~-51K 5399(ALDH18A1)(-)Loci: 3910 97061519-97190927 ~-129K 5391(SORBS1)(-)Link out to UCSC