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0P53_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameTP53
DescriptionCellular tumor antigen p53 (tumor suppressor p53) (phosphoprotein p53) (antigen ny-co-13).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005739 mitochondrion (IDA)
0005730 nucleolus (IDA)
0005524 ATP binding (IDA)
0005507 copper ion binding (IDA)
0000739 DNA strand annealing activity (IDA)
0004518 nuclease activity (TAS)
0005515 protein binding (IPI)
0046982 protein heterodimerization activity (IPI)
0003700 transcription factor activity (IDA)
0008270 zinc ion binding (TAS)
0006915 apoptosis (IDA)
0006284 base-excision repair (TAS)
0008635 caspase activation via cytochrome c (IDA)
0007569 cell aging (IMP)
0007050 cell cycle arrest (TAS)
0000075 cell cycle checkpoint (TAS)
0030154 cell differentiation (TAS)
0008283 cell proliferation (TAS)
0008630 DNA damage response, signal transduction re... (TAS)
0006310 DNA recombination (TAS)
0008628 induction of apoptosis by hormones (TAS)
0030308 negative regulation of cell growth (IMP)
0051097 negative regulation of helicase activity (TAS)
0006289 nucleotide-excision repair (IMP)
0051262 protein tetramerization (TAS)
0046902 regulation of mitochondrial membrane permea... (TAS)
0006355 regulation of transcription, DNA-dependent (IDA)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The p53 protein is a tetrameric transcription factor that plays a central role in the prevention of neoplastic transformation . Oligomerization appears to be essential for the tumour suppressing activity of p53. p53 can be divided into different functional domains: an N-terminal transactivation domain. proline-rich domain. DNA-binding domain (). tetramerisation domain and a C-terminal regulatory region. The tetramerisation domain of human p53 extends from residues 325 to 356.nd has a 4-helical bundle fold. The tetramerisation domain is essential for DNA binding.rotein-protein interactions.ost-translational modifications.nd p53 degradation .
  IPR010991:p53, tetramerisation
The binding of this protein by regulatory proteins regulates p53 transcription activation. This entry is comprised of a single amphipathic alpha helix and contains a highly conserved motif .
  IPR013872:p53 transactivation domain (TAD)
The p53 tumor antigen is a protein found in increased amounts in a wide variety of transformed cells. It is also detectable in many proliferating nontransformed cells.ut it is undetectable or present at low levels in resting cells. It is frequently mutated or inactivated in many types of cancer. p53 seems to act as a tumor suppressor in some.ut probably not all.umor types. p53 has been implicated in cell cycle regulation.articularly in the monitoring of genomic DNA integrity prior to replication; for this reason it has been dubbed guardian of the genome. P53 is a sequence-specific DNA-binding protein and transcription factor; downstream vertebrate species; attempts to identify p53 in other eukaryotic philum has so far been unsuccessful. The structure of P53 comprises 4 domains: an N-terminal transactivation domain; a central DNA-binding domain; an oligomerisation domain; and a C-terminal.asic.egulatory domain . The structure of the oligomerisation domain consists of a dimer of dimers.ach dimer consisting of 2 anti-parallel alpha-helices and an anti-parallel beta-sheet. The sheets lie on opposite sides of the tetramer and the helices form an unusual 4-helix bundle . While the majority of P53 mutations found in human cancers are located in the DNA-binding domain.ome are also found in the oligomerisation domain.
  IPR002117:p53 tumor antigen
This domain is found in a number of transcription factors.ncluding p53.FATC.onEBP.TAT-1.nd NFkappaB.here it is responsible for DNA-binding. These transcription factors play diverse roles in the regulation of cellular functions: the p53 tumour suppressor upregulates the expression of genes involved in cell cycle arrest and apoptosis ; NFATC regulates the production of effector proteins involved in coordinating the immune response ; TonEBP regulates gene expression induced by osmotic stress and helps regulate intracellular volume during cell growth ; STAT-1 plays an important role in B lymphocyte growth and function ; and NFkappaB is involved in the inflammatory response . The DNA-binding domain acts to clamp.r in the case of TonEBP.ncircle the DNA target in order to stabilize the protein-DNA complex . Protein interactions may also serve to stabilize the protein-DNA complex.or example in the STAT-1 dimer the SH2 (Src homology 2) domain in each monomer is coupled to the DNA-binding domain to increase stability . The DNA-binding domain consists of a beta-sandwich formed of 9 strands in 2 sheets with a Greek-key topology. This structure is found in many transcription factors.ften within the DNA-binding domain.The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR008967:p53-like transcription factor, DNA-binding
This domain is found in p53 transcription factors.here it is responsible for DNA-binding. These transcription factors play diverse roles in the regulation of cellular functions: the p53 tumour suppressor upregulates the expression of genes involved in cell cycle arrest and apoptosis . The DNA-binding domain acts to clamp.r in the case of TonEBP.ncircle the DNA target in order to stabilize the protein-DNA complex . Protein interactions may also serve to stabilize the protein-DNA complex.or example in the STAT-1 dimer the SH2 (Src homology 2) domain in each monomer is coupled to the DNA-binding domain to increase stability . The DNA-binding domain consists of a beta-sandwich formed of 9 strands in 2 sheets with a Greek-key topology. This structure is found in many transcription factors.ften within the DNA-binding domain.
  IPR011615:p53, DNA-binding
This DNA-binding domain is found in the p53 and the RUNT families of transcription factors. The DNA-binding domain acts to clamp or encircle the DNA target in order to stabilize the protein-DNA complex. This domain has an immunoglobulin-like fold consisting of a beta-sandwich of 9 strands in two sheets with a Greek key topology . The p53 tumour suppressor functions primarily as a sequence-specific transcription factor.ut also has transcription-independent roles in DNA repair and recombination . In addition.53.s well as its family members p63 and p73.re involved in the survival/death checkpoint in peripheral and central neurons.here full-length proteins appear to be involved in cell death.nd truncated isoforms that retain the DNA-binding domain are involved in cell survival .RUNT domain (RD) proteins (also known as RUNX.ML.BF-alpha and PEBP2-alpha) are a family of transcription factors involved in various developmental pathways. The RD has two general functions: it directs the binding of the protein to a target sequence.yGPyGGTPy (Py=pyrimidine).n order to regulate the expression of target genes; and it mediates protein-protein interactions with CBF-beta which modulates the DNA-binding affinity of the RD .
  IPR012346:p53 and RUNT-type transcription factor, DNA-binding
IPR011615:P53 
Evalue:-149.958602905273 
Location:95-289IPR010991:P53_tetramer 
Evalue:-21.8239078521729 
Location:318-359IPR013872:P53_TAD 
Evalue:-10.0132284164429 
Location:5-29
SequencesProtein: P53_HUMAN (393 aa)
mRNA: NM_000546
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords)
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
calcium-regulated transcription factor
sdb:0215 calcium-regulated transcription factor  (Evidence:keywords)
the generation of action potential at soma of neurons.
sdb:0313 generation of AP at soma  (Evidence:keywords)
KO assignmentK04451
  Level 3 annotation:
    tumor protein p53
  Level 2 annotation:
    MAPK signaling pathway
    Wnt signaling pathway
    Cell cycle
    Apoptosis
    Amyotrophic lateral sclerosis (ALS)
    Huntington's disease
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 430 residues, 7512446-7513733Exon2: 37 residues, 7514651-7514758Exon3: 22 residues, 7517249-7517309Exon4: 26 residues, 7517577-7517651Exon5: 47 residues, 7517743-7517880Exon6: 38 residues, 7518223-7518333Exon7: 39 residues, 7518901-7519014Exon8: 63 residues, 7519095-7519279Exon9: 95 residues, 7520036-7520315Exon10: 9 residues, 7520424-7520446Exon11: 36 residues, 7520563-7520665Exon12: 37 residues, 7531419-7531524Exon13: 2 residues, -Jump to P53_HUMANExon1: 430 residues, 7512446-7513733Exon2: 37 residues, 7514651-7514758Exon3: 46 residues, 7517249-7517382Exon4: 26 residues, 7517577-7517651Exon5: 47 residues, 7517743-7517880Exon6: 38 residues, 7518223-7518333Exon7: 39 residues, 7518901-7519014Exon8: 63 residues, 7519095-7519279Exon9: 95 residues, 7520036-7520315Exon10: 9 residues, 7520424-7520446Exon11: 36 residues, 7520563-7520665Exon12: 37 residues, 7531419-7531524Exon13: 2 residues, -Jump to P53_HUMANExon1: 424 residues, 7512464-7513733Exon2: 37 residues, 7514651-7514758Exon3: 26 residues, 7517577-7517651Exon4: 47 residues, 7517743-7517880Exon5: 38 residues, 7518223-7518333Exon6: 39 residues, 7518901-7519014Exon7: 63 residues, 7519095-7519279Exon8: 95 residues, 7520036-7520315Exon9: 9 residues, 7520424-7520446Exon10: 36 residues, 7520563-7520665Exon11: 76 residues, 7531419-7531642Exon12: 2 residues, -Jump to P53_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 4258 6644024-6675784 ~-32K 14997(TEKT1)(-)Loci: 4259 7033935-7063745 ~-30K 15014(DLG4)(-)Loci: 2974 7063876-7069308 ~-5K 15016(ACADVL)(+)Loci: 4260 7084462-7086477 ~-2K 15021(GABARAP)(-)Loci: 2975 7252225-7263903 ~-12K 15047(NLGN2)(+)Loci: 2976 7289129-7301655 ~-13K 15051(CHRNB1)(+)Loci: 2977 7427889-7432228 ~-4K 15066(MPDU1)(+)Loci: 2978 7474184-7477419 ~-3K 15071(SHBG)(+)Loci: 4261 7512446-7531642 ~-19K 15074(TP53)(-)Loci: 4262 7774391-7775983 ~-2K 15094(TRAPPC1)(-)Loci: 2979 7846716-7864382 ~-18K 15097(GUCY2D)(+)Loci: 4263 8004447-8006987 ~-3K 15108(VAMP2)(-)Loci: 2980 8093361-8114528 ~-21K 15119(PFAS)(+)Loci: 2981 8279988-8330396 ~-50K 15135(+)Loci: 2973 6620295-6631688 ~-11K 14996(FBXO39)(+)Link out to UCSC