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0OXSR1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameOXSR1
DescriptionSerine/threonine-protein kinase osr1 (ec 2.7.1.37) (oxidative-stress responsive 1 protein).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005524 ATP binding (IDA)
0000287 magnesium ion binding (IDA)
0005515 protein binding (IPI)
0004674 protein serine/threonine kinase activity (IDA)
0006468 protein amino acid phosphorylation (IDA)
0007243 protein kinase cascade (IDA)
0006979 response to oxidative stress (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Eukaryotic protein kinases are enzymesthat belong to a very extensive family of proteins which share a conserved catalytic core common withboth serine/threonine and tyrosine protein kinases. There are a number of conserved regions in thecatalytic domain of protein kinases. In the N-terminal extremity of the catalytic domain there is aglycine-rich stretch of residues in the vicinity of a lysine residue.hich has been shown to be involvedin ATP binding. In the central part of the catalytic domain there is a conserved aspartic acid residuewhich is important for the catalytic activity of the enzyme . CAUTION: Despite SMART having created two different HMMs for Serine/Threonine protein kinase and for Tyrosine protein kinase.arge number of proteins match both signatures.s SMART considers it to be natural for these two closely related families.
  IPR002290:Serine/threonine protein kinase
Eukaryotic protein kinases are enzymesthat belong to a very extensive family of proteins which share a conserved catalytic core common withboth serine/threonine and tyrosine protein kinases. There are a number of conserved regions in thecatalytic domain of protein kinases. In the N-terminal extremity of the catalytic domain there is aglycine-rich stretch of residues in the vicinity of a lysine residue.hich has been shown to be involvedin ATP binding. In the central part of the catalytic domain there is a conserved aspartic acid residuewhich is important for the catalytic activity of the enzyme . This entry includes protein kinases from eukaryotes and viruses and may include some bacterial hits too.
  IPR000719:Protein kinase
Protein kinases () catalyze the phosphotransfer reaction fundamental to most signalling and regulatory processes in the eukaryotic cell . The catalytic subunit contains a core that is common to both serine/threonine and tyrosine protein kinases. The catalytic domain contains the nucleotide-binding site and the catalytic apparatus in an inter-lobe cleft. Structurally it shares functional and structural similarities with the ATP-grasp fold.hich is found in enzymes that catalyse the formation of an amide bond.nd with PIPK (phosphoinositol phosphate kinase). The three-dimensional fold of the protein kinase catalytic domain is similar to domains found in several other proteins. These include the catalytic domain of actin-fragmin kinase.n atypical protein kinase that regulates the F-actin capping activity in plasmodia ; the catalytic domain of phosphoinositide-3-kinase (PI3K).hich phosphorylates phosphoinositides and as such is involved in a number of fundamental cellular processes such as apoptosis.roliferation.otility and adhesion ; the catalytic domain of the MHCK/EF2 kinase.n atypical protein kinase that includes the TRP (transient channel potential) calcium-channel kinase involved in the modulation of calcium channels in eukaryotic cells in response to external signals ; choline kinase.hich catalyses the ATP-dependent phosphorylation of choline during the biosynthesis of phosphatidylcholine ; and 3.-aminoglycoside phosphotransferase type IIIa. bacterial enzyme that confers resistance to a range of aminoglycoside antibiotics .
  IPR011009:Protein kinase-like
IPR002290:S_TKc 
Evalue:-84.0222763947111 
Location:17-291IPR008271:PROTEIN_KINASE_ST 
Evalue:0 
Location:0-0
SequencesProtein: OXSR1_HUMAN (527 aa)
mRNA: NM_005109
Local Annotation
Synapse Ontology
activation of protein kinase C
sdb:0206 activation of protein kinase C  (Evidence:keywords)
KO assignmentK00870
  Level 3 annotation:
    protein kinase
  Level 2 annotation:
    Signal transduction mechanisms
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 138 residues, 38182029-38182441Exon2: 39 residues, 38199497-38199610Exon3: 38 residues, 38207225-38207334Exon4: 49 residues, 38215216-38215358Exon5: 20 residues, 38232590-38232646Exon6: 38 residues, 38238072-38238182Exon7: 36 residues, 38240306-38240408Exon8: 46 residues, 38241065-38241199Exon9: 18 residues, 38246181-38246230Exon10: 24 residues, 38246859-38246925Exon11: 43 residues, 38253333-38253456Exon12: 14 residues, 38259237-38259273Exon13: 51 residues, 38262569-38262716Exon14: 23 residues, 38264162-38264227Exon15: 19 residues, 38266460-38266513Exon16: 25 residues, 38267897-38267966Exon17: 23 residues, 38268822-38268887Exon18: 892 residues, 38269311-38271982Exon19: 2 residues, -Jump to OXSR1_HUMAN  
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Loci Cluster (Details)Loci: 4592 38024010-38046119 ~-22K 25407(PLCD1)(-)Loci: 3348 38182029-38271982 ~-90K 25418(OXSR1)(+)Loci: 4593 38564557-38666167 ~-102K 25429(SCN5A)(-)Loci: 4594 38713841-38810505 ~-97K 25434(SCN10A)(-)Loci: 4595 38862263-38967056 ~-105K 25435(SCN11A)(-)Loci: 3347 38004533-38023679 ~-19K 25403(VILL)(+)Link out to UCSC