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0OX1R_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameHCRTR1
DescriptionOrexin receptor type 1 (ox1r) (hypocretin receptor type 1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (TAS)
0004930 G-protein coupled receptor activity (TAS)
0007631 feeding behavior (TAS)
0007218 neuropeptide signaling pathway (TAS)
0007268 synaptic transmission (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .The hypothalamus plays a central role in the integrated control of feedingand energy homeostasis . A new family of neuropeptides.rexins.avebeen identified that bind and activate two closely related (previously)orphan GPCRs . Orexins stimulate appetite and food consumption .Their genes are expressed bilaterally and symmetrically in the lateralhypothalamus.hich has been shown to be the feeding centre. By contrast.he satiety centre is expressed in the ventromedial hypothalamus and isdominated by the leptin-regulated neuropeptide network.
  IPR000204:Orexin receptor
InterPro domains unassigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .
  IPR000276:Rhodopsin-like GPCR superfamily
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .The hypothalamus plays a central role in the integrated control of feedingand energy homeostasis . A new family of neuropeptides.rexins.ave been identified that bind and activate two closely related (previously) orphan GPCRs . Orexins stimulate appetite and food consumption . Their genes are expressed bilaterally and symmetrically in the lateral hypothalamus.hich has been shown to be the "feeding centre". By contrast.he "satiety centre" is expressed in the ventromedial hypothalamus and is dominated by the leptin-regulated neuropeptide network.Both orexin receptors exhibit a similar pharmacology - the 2 orexin peptides.rexin-A and orexin-B.ind to both receptors and.n each case.gonist binding results in an increase in intracellular calcium levels. However.rexin-B shows a 10-fold selectivity for orexin receptor type 2.hilst orexin-A is equipotent at both receptors .
  IPR004059:Orexin receptor, type 1
IPR000276:7tm_1 
Evalue:-69.4685211181641 
Location:63-358IPR000204:OREXINR 
Evalue:0 
Location:31-47IPR000204:OREXINR 
Evalue:0 
Location:409-422IPR004059:OREXIN1R 
Evalue:0 
Location:393-404IPR000204:OREXINR 
Evalue:0 
Location:19-30
SequencesProtein: OX1R_HUMAN (425 aa)
mRNA: NM_001525
Local Annotation
Synapse Ontology
?
sdb:0219 GPCR mediated signaling  (Evidence:domains)
KO assignmentK04238
  Level 3 annotation:
    hypocretin (orexin) receptor 1
  Level 2 annotation:
    G-protein coupled receptors
    Neuroactive ligand-receptor interaction
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 118 residues, 31857227-31857579Exon2: 61 residues, 31857719-31857898Exon3: 83 residues, 31859030-31859274Exon4: 40 residues, 31859664-31859780Exon5: 77 residues, 31861710-31861937Exon6: 42 residues, 31863184-31863306Exon7: 110 residues, 31864977-31865301Exon8: 2 residues, -Jump to OX1R_HUMAN  
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Loci Cluster (Details)Loci: 3788 31965305-32002223 ~-37K 944(BAI2)(-)Loci: 2501 32417931-32436472 ~-19K 964(TXLNA)(+)Loci: 2502 32489505-32524350 ~-35K 978(LCK)(+)Loci: 3789 32572027-32574410 ~-2K 982(MARCKSL1)(-)Loci: 2500 31857227-31865301 ~-8K 939(HCRTR1)(+)Link out to UCSC