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0ORNT2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameSLC25A2
DescriptionMitochondrial ornithine transporter 2 (solute carrier family 25 member 2).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0000064 L-ornithine transporter activity (NAS)
0000066 mitochondrial ornithine transport (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
A variety of substrate carrier proteins that are involved in energy transfer are found in the inner mitochondrial membrane or integral to the membrane of other eukaryotic organelles such as the peroxisome . Such proteins include: ADP.TP carrier protein (ADP/ATP translocase); 2-oxoglutarate/malate carrier protein; phosphate carrier protein; tricarboxylate transport protein (or citrate transport protein); Graves disease carrier protein; yeast mitochondrial proteins MRS3 and MRS4; yeast mitochondrial FAD carrier protein; and many others. Structurally.hese proteins can consist of up to three tandem repeats of a domain of approximately 100 residues.ach domain containing two transmembrane regions.
  IPR001993:Mitochondrial substrate carrier
A variety of substrate carrier proteins that are involved in energy transferare found in the inner mitochondrial membrane . Such proteins include:ADP.TP carrier protein (ADP/ATP translocase); 2-oxoglutarate/malate carrierprotein; phosphate carrier protein; tricarboxylate transport protein (orcitrate transport protein); Graves disease carrier protein; yeastmitochondrial proteins MRS3 and MRS4; yeast mitochondrial FAD carrier protein;and many others.Sequence analysis of selected members of the carrier protein family hassuggested the presence of six transmembrane (TM) domains.ith varyingdegrees of sequence conservation and hydrophilicity . The TM regions.nd adjacent hydrophilic loops.re more highly conserved than otherregions of the proteins . All members of the family appear to consistof a tripartite structure.ach of the repeated segments being ~100 residuesin length . Each repeat contains two TM domains.he first being morehydrophobic.ith conserved glycyl and prolyl residues. Five of the six TMdomains are followed by the conserved sequence (D/E)-Hy(K/R){where - denotesany residue.nd Hy is a hydrophobic position} .Mitochondrial ADP/ATP translocase.n abundant component of the innermembrane.arries ATP from the matrix into the inter-membrane space andtransports ADP back . The protein is an integral membrane protein thatfunctions as a homodimer.
  IPR002113:Adenine nucleotide translocator 1
IPR001993:Mito_carr 
Evalue:-24.8538722991943 
Location:8-96IPR001993:Mito_carr 
Evalue:-24.6382713317871 
Location:208-298IPR001993:Mito_carr 
Evalue:-23.3979396820068 
Location:105-202
SequencesProtein: ORNT2_HUMAN (301 aa)
mRNA: NM_031947
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 473 residues, 140662380-140663796Exon2: 2 residues, -Jump to ORNT2_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3481 140051201-140059073 ~-8K 29557(HARSL)(+)Loci: 3482 140146059-140372113 ~-226K 29559(PCDHA1)(+)Loci: 3483 140411162-140413696 ~-3K 29584(PCDHB1)(+)Loci: 3484 140454420-140457146 ~-3K 29585(PCDHB2)(+)Loci: 3485 140460417-140463589 ~-3K 29586(PCDHB3)(+)Loci: 3486 140481764-140485385 ~-4K 29587(PCDHB4)(+)Loci: 3487 140494983-140497887 ~-3K 29588(PCDHB5)(+)Loci: 3488 140510022-140513050 ~-3K 29589(PCDHB6)(+)Loci: 3489 140532426-140536140 ~-4K 29592(PCDHB7)(+)Loci: 3490 140541163-140545979 ~-5K 29593(PCDHB16)(+)Loci: 3491 140552135-140555397 ~-3K 29594(PCDHB10)(+)Loci: 3492 140559531-140562801 ~-3K 29596(PCDHB11)(+)Loci: 3493 140568474-140571880 ~-3K 29597(PCDHB12)(+)Loci: 3494 140573692-140577177 ~-3K 29598(PCDHB13)(+)Loci: 3495 140583261-140586042 ~-3K 29599(PCDHB14)(+)Loci: 3496 140605330-140607983 ~-3K 29601(PCDHB15)(+)Loci: 4735 140662380-140663796 ~-1K 29602(SLC25A2)(-)Loci: 3497 140690435-140872730 ~-182K 29604(PCDHGA1)(+)Loci: 4736 140874772-140978691 ~-104K 29642(DIAPH1)(-)Loci: 4737 141013153-141041984 ~-29K 29650(CENTD3)(-)Loci: 4734 140033674-140051155 ~-17K 29556(HARS)(-)Link out to UCSC