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0ORNT1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameSLC25A15
DescriptionMitochondrial ornithine transporter 1 (solute carrier family 25 member 15).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0016021 integral to membrane (TAS)
0005743 mitochondrial inner membrane (TAS)
0000064 L-ornithine transporter activity (TAS)
0006520 amino acid metabolism (TAS)
0000066 mitochondrial ornithine transport (TAS)
0000050 urea cycle (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
A variety of substrate carrier proteins that are involved in energy transfer are found in the inner mitochondrial membrane or integral to the membrane of other eukaryotic organelles such as the peroxisome . Such proteins include: ADP.TP carrier protein (ADP/ATP translocase); 2-oxoglutarate/malate carrier protein; phosphate carrier protein; tricarboxylate transport protein (or citrate transport protein); Graves disease carrier protein; yeast mitochondrial proteins MRS3 and MRS4; yeast mitochondrial FAD carrier protein; and many others. Structurally.hese proteins can consist of up to three tandem repeats of a domain of approximately 100 residues.ach domain containing two transmembrane regions.
  IPR001993:Mitochondrial substrate carrier
A variety of substrate carrier proteins that are involved in energy transferare found in the inner mitochondrial membrane . Such proteins include:ADP.TP carrier protein (ADP/ATP translocase); 2-oxoglutarate/malate carrierprotein; phosphate carrier protein; tricarboxylate transport protein (orcitrate transport protein); Graves disease carrier protein; yeastmitochondrial proteins MRS3 and MRS4; yeast mitochondrial FAD carrier protein;and many others.Sequence analysis of selected members of the carrier protein family hassuggested the presence of six transmembrane (TM) domains.ith varyingdegrees of sequence conservation and hydrophilicity . The TM regions.nd adjacent hydrophilic loops.re more highly conserved than otherregions of the proteins . All members of the family appear to consistof a tripartite structure.ach of the repeated segments being ~100 residuesin length . Each repeat contains two TM domains.he first being morehydrophobic.ith conserved glycyl and prolyl residues. Five of the six TMdomains are followed by the conserved sequence (D/E)-Hy(K/R){where - denotesany residue.nd Hy is a hydrophobic position} .Mitochondrial ADP/ATP translocase.n abundant component of the innermembrane.arries ATP from the matrix into the inter-membrane space andtransports ADP back . The protein is an integral membrane protein thatfunctions as a homodimer.
  IPR002113:Adenine nucleotide translocator 1
IPR001993:Mito_carr 
Evalue:-26.3565464019775 
Location:105-202IPR001993:Mito_carr 
Evalue:-25.2441253662109 
Location:208-298IPR001993:Mito_carr 
Evalue:-21.9208183288574 
Location:8-96
SequencesProtein: ORNT1_HUMAN (301 aa)
mRNA: BC002702
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 56 residues, 40261632-40261799Exon2: 43 residues, 40265293-40265417Exon3: 88 residues, 40271192-40271451Exon4: 48 residues, 40277253-40277391Exon5: 58 residues, 40279429-40279599Exon6: 55 residues, 40280573-40280732Exon7: 97 residues, 40281678-40281965Exon8: 2 residues, -Jump to ORNT1_HUMAN  
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Loci Cluster (Details)Loci: 4095 40688516-40735713 ~-47K 10296(MTRF1)(-)Loci: 2811 40261632-40281965 ~-20K 10287(SLC25A15)(+)Link out to UCSC