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0OREX_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameHCRT
DescriptionOrexin precursor (hypocretin) (hcrt) .
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0008021 synaptic vesicle (TAS)
0007268 synaptic transmission (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Orexins (also known as hypocretins) are recently identified neuropeptides that are specifically localised to the hypothalamus. They are thought to interact with autonomic.eurendocrine and neuroregulatory systems.nd play an important role in the regulation of feeding behaviour . When applied to hypothalamic neurones.hese peptides are neuroexcitatory.hich action is probably mediated by their binding to a new family of G-protein-coupled receptors (orexin receptors 1 and 2).hich were previously orphan .To date.wo orexins have been characterised (orexin-A and -B).oth encoded by a single mRNA transcript (prepro-orexin): orexin-A is a 33-residue peptide with two intramolecular disulphide bonds in the N-terminal region; and orexin-B is a linear 28-residue peptide. These peptides have 46% identity at the amino acid sequence level.nd show some similarity to the glucagon/vasoactive intestinal polypeptide/secretin peptide family.
  IPR001704:Prepro-orexin
IPR001704:Orexin 
Evalue:-96.1870880126953 
Location:1-131
SequencesProtein: OREX_HUMAN (131 aa)
mRNA: NM_001524
Local Annotation
Synapse Ontology
introduce the substructure of the synapse and the location where the molecule can be seen. It will contain all the constructive special organelle and molecule we known.
sdb:0001 Structure/Biochemistry of synapse  (Evidence:keywords)
Various stages of the synaptic vesicle cycle, including attachment, prefusion, triggering, recycling and reloading of the vesicles with transmitter.
sdb:0098 synaptic vesicle cycling  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 157 residues, 37589603-37590072Exon2: 38 residues, 37590888-37590996Exon3: 2 residues, -Jump to OREX_HUMAN  
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Loci Cluster (Details)Loci: 4288 37562438-37586822 ~-24K 15872(KCNH4)(-)Loci: 4289 37589603-37590996 ~-1K 15873(HCRT)(-)Loci: 3002 37864387-37928122 ~-64K 15882(ATP6V0A1)(+)Loci: 3003 37941476-37949990 ~-9K 15887(NAGLU)(+)Loci: 3004 38064836-38072549 ~-8K 15898(TUBG2)(+)Loci: 3005 38088157-38105358 ~-17K 15903(CNTNAP1)(+)Loci: 4290 38105819-38150574 ~-45K 15904(EZH1)(-)Loci: 3006 38186221-38202605 ~-16K 15907(WNK4)(+)Loci: 4291 38215677-38229807 ~-14K 15912(BECN1)(-)Loci: 3007 38250134-38256248 ~-6K 15916(AOC2)(+)Loci: 3008 38256726-38263664 ~-7K 15917(AOC3)(+)Loci: 4292 38420147-38427921 ~-8K 15927(VAT1)(-)Loci: 4293 38449839-38530657 ~-81K 15931(BRCA1)(-)Loci: 4287 37530523-37560548 ~-30K 15871(RAB5C)(-)Link out to UCSC