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0OPRX_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameOPRL1
DescriptionNociceptin receptor (orphanin fq receptor) (kappa-type 3 opioid receptor) (kor-3).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (TAS)
0004930 G-protein coupled receptor activity (IGI)
0007204 elevation of cytosolic calcium ion concentr... (IGI)
0007193 G-protein signaling, adenylate cyclase inhi... (TAS)
0007600 sensory perception (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .The term opioid refers to a class of substance that produces its effectsvia the major classes of opioid receptor.ermed mu.elta and kappa .The receptors are found in the CNS and certain smooth muscles: mu-opioidreceptors are believed to mediate analgesia.ypothermia.espiratorydepression.iosis.radycardia.ausea.uphoria and physical dependence.eta-endorphin being the most potent endogenous ligand; delta-receptorsmediate analgesia; and kappa-opioid receptors are believed to mediateanalgesia.edation.iosis and diuresis.ynorphin being the most potentendogenous ligand.A human placental protein that binds opioid ligands with moderate affinityhas been provisionally classified as an opioid receptor . However.t isnot selective for kappa-ligands and is 93% similar to the human NK3tachykinin receptor.lthough it doesnt bind tachykinins.
  IPR001418:Opioid receptor
InterPro domains unassigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .
  IPR000276:Rhodopsin-like GPCR superfamily
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .The term opioid refers to a class of substance that produces its effectsvia the major classes of opioid receptor.ermed mu.elta and kappa .The receptors are found in the CNS and certain smooth muscles: mu-opioidreceptors are believed to mediate analgesia.ypothermia.espiratorydepression.iosis.radycardia.ausea.uphoria and physical dependence.eta-endorphin being the most potent endogenous ligand; delta-receptorsmediate analgesia; and kappa-opioid receptors are believed to mediateanalgesia.edation.iosis and diuresis.ynorphin being the most potentendogenous ligand.The X-receptor is closely related to opioid receptors.n grounds of bothsequence and function.lthough it is not a typical opioid receptor .X-receptors are found in many regions of the brain and spinal cord.articularly limbic and hypothalamic structures. They are believed torepresent a new class of opioid receptors.ith a potential role inmodulating various brain functions.ncluding instinctive behaviours andemotions .
  IPR001420:X opioid receptor
IPR000276:7tm_1 
Evalue:-87.4202194213867 
Location:68-319IPR001420:XOPIOIDR 
Evalue:0 
Location:33-51IPR001420:XOPIOIDR 
Evalue:0 
Location:351-368IPR001420:XOPIOIDR 
Evalue:0 
Location:335-347IPR001420:XOPIOIDR 
Evalue:0 
Location:7-19IPR001418:OPIOIDR 
Evalue:0 
Location:321-330
SequencesProtein: OPRX_HUMAN (370 aa)
mRNA: AF115266 NM_182647
Local Annotation
Synapse Ontology
focus on function of synapse, corresponding to the structure of synapse.
sdb:0003 physiology/function at synapse  (Evidence:domains)
the plasma membrane of the postsynaptic neuron. It apposes with presynaptic actiove zone.
sdb:0108 postsynaptic plasma membrane  (Evidence:domains)
KO assignmentK04216
  Level 3 annotation:
    opiate receptor-like 1
  Level 2 annotation:
    G-protein coupled receptors
    Neuroactive ligand-receptor interaction
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 73 residues, 62181931-62182149Exon2: 52 residues, 62193762-62193913Exon3: 90 residues, 62194484-62194750Exon4: 120 residues, 62199598-62199954Exon5: 789 residues, 62200072-62202435Exon6: 2 residues, -Jump to OPRX_HUMANExon1: 93 residues, 62194502-62194778Exon2: 120 residues, 62199598-62199954Exon3: 183 residues, 62200072-62200617Exon4: 2 residues, -Jump to OPRX_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3279 60906621-60915796 ~-9K 23505(OGFR)(+)Loci: 3280 61337720-61342298 ~-5K 23526(BIRC7)(+)Loci: 4537 61448389-61463100 ~-15K 23536(CHRNA4)(-)Loci: 4538 61507985-61574437 ~-66K 23542(KCNQ2)(-)Loci: 4539 61630221-61639151 ~-9K 23549(PTK6)(-)Loci: 4540 61642606-61649301 ~-7K 23550(SRMS)(-)Loci: 4541 61659883-61676033 ~-16K 23552(PRIC285)(-)Loci: 4542 61689398-61721673 ~-32K 23556(GMEB2)(-)Loci: 3281 61996961-62035838 ~-39K 23585(DNAJC5)(+)Loci: 3282 62082900-62134895 ~-52K 23593(C20orf14)(+)Loci: 3283 62181931-62202435 ~-21K 23600(OPRL1)(+)Loci: 3278 60810633-60864567 ~-54K 23503(NTSR1)(+)Link out to UCSC