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0OPRD_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameOPRD1
DescriptionDelta-type opioid receptor (dor-1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (TAS)
0005886 plasma membrane (TAS)
0004986 delta-opioid receptor activity (TAS)
0007187 G-protein signaling, coupled to cyclic nucl... (TAS)
0006955 immune response (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .The term opioid refers to a class of substance that produces its effectsvia the major classes of opioid receptor.ermed mu.elta and kappa .The delta opioid receptor has a more discrete distribution in the CNSrelative to the mu and kappa opioid receptors: it is found in the cerebralcortex.mygdala.ucleus accumbens.lfactory tubercle and pontinenucleus. It is also found in certain smooth muscles..g. hamster vasdeferens.nd in cell lines . Delta-receptors mediate analgesia.
  IPR000321:Delta opioid receptor
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .The term opioid refers to a class of substance that produces its effectsvia the major classes of opioid receptor.ermed mu.elta and kappa .The receptors are found in the CNS and certain smooth muscles: mu-opioidreceptors are believed to mediate analgesia.ypothermia.espiratorydepression.iosis.radycardia.ausea.uphoria and physical dependence.eta-endorphin being the most potent endogenous ligand; delta-receptorsmediate analgesia; and kappa-opioid receptors are believed to mediateanalgesia.edation.iosis and diuresis.ynorphin being the most potentendogenous ligand.A human placental protein that binds opioid ligands with moderate affinityhas been provisionally classified as an opioid receptor . However.t isnot selective for kappa-ligands and is 93% similar to the human NK3tachykinin receptor.lthough it doesnt bind tachykinins.
  IPR001418:Opioid receptor
InterPro domains unassigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .
  IPR000276:Rhodopsin-like GPCR superfamily
IPR000276:7tm_1 
Evalue:-95.7958831787109 
Location:66-318IPR000321:DELTAOPIOIDR 
Evalue:0 
Location:351-369IPR000321:DELTAOPIOIDR 
Evalue:0 
Location:32-46IPR000321:DELTAOPIOIDR 
Evalue:0 
Location:18-31IPR000321:DELTAOPIOIDR 
Evalue:0 
Location:334-346IPR001418:OPIOIDR 
Evalue:0 
Location:320-329
SequencesProtein: OPRD_HUMAN (372 aa)
mRNA: NM_000911
Local Annotation
Synapse Ontology
focus on function of synapse, corresponding to the structure of synapse.
sdb:0003 physiology/function at synapse  (Evidence:domains)
the plasma membrane of the postsynaptic neuron. It apposes with presynaptic actiove zone.
sdb:0108 postsynaptic plasma membrane  (Evidence:domains)
KO assignmentK04213
  Level 3 annotation:
    opioid receptor, delta 1
  Level 2 annotation:
    G-protein coupled receptors
    Neuroactive ligand-receptor interaction
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 157 residues, 29011240-29011709Exon2: 118 residues, 29058052-29058402Exon3: 320 residues, 29061840-29062795Exon4: 2 residues, -Jump to OPRD_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 2499 29086214-29319545 ~-233K 907(EPB41)(+)Loci: 2498 29011240-29062795 ~-52K 905(OPRD1)(+)Link out to UCSC