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0OPA1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameOPA1
DescriptionDynamin-like 120 kda protein, mitochondrial precursor (optic atrophy 1 gene protein).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0030425 dendrite (ISS)
0030061 mitochondrial crista (IDA)
0005758 mitochondrial intermembrane space (ISS)
0005741 mitochondrial outer membrane (IDA)
0003924 GTPase activity (TAS)
0000287 magnesium ion binding (NAS)
0019896 axon transport of mitochondrion (TAS)
0007007 inner mitochondrial membrane organization a... (IDA)
0000266 mitochondrial fission (TAS)
0008053 mitochondrial fusion (TAS)
0045768 positive regulation of anti-apoptosis (IDA)
0007601 visual perception (IMP)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Membrane transport between compartments in eukaryotic cells requires proteins that allow the budding and scission of nascent cargo vesicles from one compartment and their targeting and fusion with another. Dynamins are large GTPases that belong to a protein superfamily that.n eukaryotic cells.ncludes classical dynamins.ynamin-like proteins.PA1.x proteins.itofusins and guanylate-binding proteins/atlastins and are involved in the scission of a wide range of vesicles and organelles. They play a role in many processes including budding of transport vesicles.ivision of organelles.ytokinesis and pathogen resistance. The minimal distinguishing architectural features that are common to all dynamins and are distinct from other GTPases are the structure of the large GTPase domain (300 amino acids) and the presence of two additional domains; the middle domain and the GTPase effector domain (GED).hich are involved in oligomerization and regulation of the GTPase activity. The GTPase domain contains the GTP-binding motifs that are needed for guanine-nucleotide binding and hydrolysis. The conservation of these motifs is absolute except for the the final motif in guanylate-binding proteins. The GTPase catalytic activity can be stimulated by oligomerisation of the protein.hich is mediated by interactions between the GTPase domain.he middle domain and the GED.
  IPR001401:Dynamin
IPR001401:Dynamin_N 
Evalue:-58.0315170288086 
Location:291-469
SequencesProtein: OPA1_HUMAN (960 aa)
mRNA: NM_015560 NM_130834 NM_130836 NM_130837
Local Annotation
Synapse Ontology
The directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell.
sdb:0057 axon transport  (Evidence:keywords)
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 30 residues, 194793805-194793892Exon2: 108 residues, 194815205-194815524Exon3: 34 residues, 194816156-194816253Exon4: 38 residues, 194817660-194817768Exon5: 20 residues, 194818266-194818320Exon6: 24 residues, 194819351-194819419Exon7: 39 residues, 194826574-194826685Exon8: 20 residues, 194832094-194832148Exon9: 37 residues, 194835900-194836005Exon10: 31 residues, 194837677-194837764Exon11: 40 residues, 194838434-194838548Exon12: 29 residues, 194843247-194843328Exon13: 27 residues, 194843457-194843532Exon14: 26 residues, 194843855-194843927Exon15: 35 residues, 194844010-194844110Exon16: 45 residues, 194844457-194844588Exon17: 26 residues, 194846035-194846108Exon18: 26 residues, 194846210-194846283Exon19: 40 residues, 194847547-194847663Exon20: 23 residues, 194848552-194848617Exon21: 27 residues, 194849277-194849354Exon22: 57 residues, 194855344-194855510Exon23: 53 residues, 194857562-194857715Exon24: 38 residues, 194859369-194859478Exon25: 28 residues, 194859964-194860044Exon26: 49 residues, 194863304-194863445Exon27: 41 residues, 194865362-194865479Exon28: 33 residues, 194866778-194866872Exon29: 39 residues, 194867652-194867763Exon30: 25 residues, 194892545-194892615Exon31: 975 residues, 194895088-194898009Exon32: 2 residues, -Jump to OPA1_HUMANExon1: 30 residues, 194793805-194793892Exon2: 108 residues, 194815205-194815524Exon3: 34 residues, 194816156-194816253Exon4: 38 residues, 194817660-194817768Exon5: 20 residues, 194818266-194818320Exon6: 24 residues, 194819351-194819419Exon7: 20 residues, 194832094-194832148Exon8: 37 residues, 194835900-194836005Exon9: 31 residues, 194837677-194837764Exon10: 40 residues, 194838434-194838548Exon11: 29 residues, 194843247-194843328Exon12: 27 residues, 194843457-194843532Exon13: 26 residues, 194843855-194843927Exon14: 35 residues, 194844010-194844110Exon15: 45 residues, 194844457-194844588Exon16: 26 residues, 194846035-194846108Exon17: 26 residues, 194846210-194846283Exon18: 40 residues, 194847547-194847663Exon19: 23 residues, 194848552-194848617Exon20: 27 residues, 194849277-194849354Exon21: 57 residues, 194855344-194855510Exon22: 53 residues, 194857562-194857715Exon23: 38 residues, 194859369-194859478Exon24: 28 residues, 194859964-194860044Exon25: 49 residues, 194863304-194863445Exon26: 41 residues, 194865362-194865479Exon27: 33 residues, 194866778-194866872Exon28: 39 residues, 194867652-194867763Exon29: 25 residues, 194892545-194892615Exon30: 975 residues, 194895088-194898009Exon31: 2 residues, -Jump to OPA1_HUMANExon1: 30 residues, 194793805-194793892Exon2: 108 residues, 194815205-194815524Exon3: 34 residues, 194816156-194816253Exon4: 38 residues, 194817660-194817768Exon5: 24 residues, 194819351-194819419Exon6: 39 residues, 194826574-194826685Exon7: 20 residues, 194832094-194832148Exon8: 37 residues, 194835900-194836005Exon9: 31 residues, 194837677-194837764Exon10: 40 residues, 194838434-194838548Exon11: 29 residues, 194843247-194843328Exon12: 27 residues, 194843457-194843532Exon13: 26 residues, 194843855-194843927Exon14: 35 residues, 194844010-194844110Exon15: 45 residues, 194844457-194844588Exon16: 26 residues, 194846035-194846108Exon17: 26 residues, 194846210-194846283Exon18: 40 residues, 194847547-194847663Exon19: 23 residues, 194848552-194848617Exon20: 27 residues, 194849277-194849354Exon21: 57 residues, 194855344-194855510Exon22: 53 residues, 194857562-194857715Exon23: 38 residues, 194859369-194859478Exon24: 28 residues, 194859964-194860044Exon25: 49 residues, 194863304-194863445Exon26: 41 residues, 194865362-194865479Exon27: 33 residues, 194866778-194866872Exon28: 39 residues, 194867652-194867763Exon29: 25 residues, 194892545-194892615Exon30: 975 residues, 194895088-194898009Exon31: 2 residues, -Jump to OPA1_HUMANExon1: 30 residues, 194793805-194793892Exon2: 108 residues, 194815205-194815524Exon3: 34 residues, 194816156-194816253Exon4: 38 residues, 194817660-194817768Exon5: 24 residues, 194819351-194819419Exon6: 20 residues, 194832094-194832148Exon7: 37 residues, 194835900-194836005Exon8: 31 residues, 194837677-194837764Exon9: 40 residues, 194838434-194838548Exon10: 29 residues, 194843247-194843328Exon11: 27 residues, 194843457-194843532Exon12: 26 residues, 194843855-194843927Exon13: 35 residues, 194844010-194844110Exon14: 45 residues, 194844457-194844588Exon15: 26 residues, 194846035-194846108Exon16: 26 residues, 194846210-194846283Exon17: 40 residues, 194847547-194847663Exon18: 23 residues, 194848552-194848617Exon19: 27 residues, 194849277-194849354Exon20: 57 residues, 194855344-194855510Exon21: 53 residues, 194857562-194857715Exon22: 38 residues, 194859369-194859478Exon23: 28 residues, 194859964-194860044Exon24: 49 residues, 194863304-194863445Exon25: 41 residues, 194865362-194865479Exon26: 33 residues, 194866778-194866872Exon27: 39 residues, 194867652-194867763Exon28: 25 residues, 194892545-194892615Exon29: 975 residues, 194895088-194898009Exon30: 2 residues, -Jump to OPA1_HUMAN  
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