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0OGFR_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameOGFR
DescriptionOpioid growth factor receptor (ogfr) (zeta-type opioid receptor) (7-60 protein).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0004985 opioid receptor activity (NAS)
0001558 regulation of cell growth (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Opioid peptides act as growth factors in neural and non-neural cells and tissues.n addition to serving in neurotransmission/neuromodulation in the nervous system. The opioid growth factor receptor is an integral membrane protein associated with the nucleus. This conserved region is situated at the N-terminus of the member proteins with a series of imperfect repeats lying immediately to its C-terminal .
  IPR006757:Opioid growth factor receptor (OGFr) conserved region
Opioid peptides act as growth factors in neural and non-neural cells and tissues.n addition to serving for neurotransmission/neuromodulation in the nervous system. The native opioid growth factor (OGF).Met(5)]-enkephalin.s an inhibitory peptide that plays a role in cell proliferation and tissue organization during development.ancer.ellular renewal.ound healing.nd angiogenesis. OGF action is mediated by a receptor mechanism.he receptor for OGF (OGFr) is an integral membrane protein associated with the nucleus. OGFr is distinguished by containing a series of imperfect repeats. This entry describes a proline-rich repeat found in a human opioid growth factor receptor .
  IPR006770:Opioid growth factor receptor repeat
IPR006757:OGFr_N 
Evalue:-146.638275146484 
Location:81-295IPR006770:OGFr_III 
Evalue:-8 
Location:577-596IPR006770:OGFr_III 
Evalue:-7.72124624252319 
Location:537-556IPR006770:OGFr_III 
Evalue:-7.72124624252319 
Location:557-576IPR006770:OGFr_III 
Evalue:-7.72124624252319 
Location:597-616IPR006770:OGFr_III 
Evalue:-7.72124624252319 
Location:617-636IPR006770:OGFr_III 
Evalue:-7.42021656036377 
Location:637-656IPR006770:OGFr_III 
Evalue:-7.39794015884399 
Location:517-536
SequencesProtein: OGFR_HUMAN (677 aa)
mRNA: NM_007346
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 69 residues, 60906621-60906827Exon2: 25 residues, 60909333-60909402Exon3: 28 residues, 60910043-60910122Exon4: 28 residues, 60911381-60911460Exon5: 24 residues, 60912295-60912362Exon6: 51 residues, 60913258-60913407Exon7: 592 residues, 60914026-60915796Exon8: 2 residues, -Jump to OGFR_HUMAN  
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Loci Cluster (Details)Loci: 3279 60906621-60915796 ~-9K 23505(OGFR)(+)Loci: 3280 61337720-61342298 ~-5K 23526(BIRC7)(+)Loci: 4537 61448389-61463100 ~-15K 23536(CHRNA4)(-)Loci: 4538 61507985-61574437 ~-66K 23542(KCNQ2)(-)Loci: 4539 61630221-61639151 ~-9K 23549(PTK6)(-)Loci: 4540 61642606-61649301 ~-7K 23550(SRMS)(-)Loci: 4541 61659883-61676033 ~-16K 23552(PRIC285)(-)Loci: 4542 61689398-61721673 ~-32K 23556(GMEB2)(-)Loci: 3281 61996961-62035838 ~-39K 23585(DNAJC5)(+)Loci: 3282 62082900-62134895 ~-52K 23593(C20orf14)(+)Loci: 3283 62181931-62202435 ~-21K 23600(OPRL1)(+)Loci: 3278 60810633-60864567 ~-54K 23503(NTSR1)(+)Link out to UCSC