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0ODPX_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NamePDHX
DescriptionPyruvate dehydrogenase protein x component, mitochondrial precursor (dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex) (lipoyl-containing pyruvate dehydrogenase complex component x) (e3-binding protein) (e3bp) (prox).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005967 pyruvate dehydrogenase complex (sensu Eukar... (TAS)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The biotin / lipoyl attachment domain has a conserved lysine residue that binds biotin or lipoicacid. Biotin plays a catalytic role in some carboxyl transfer reactions and is covalently attached.ia an amide bond.o a lysine residue in enzymes requiring this coenzyme . E2 acyltransferases have an essential cofactor.ipoic acid.hich is covalently bound via an amide linkage to a lysine group . The lipoic acid cofactor is found in a variety of proteins that include.-protein of the glycine cleavage system (GCS).ammalian and yeast pyruvate dehydrogenases and fast migrating protein (FMP) (gene acoC) from Alcaligenes eutrophus.
  IPR000089:Biotin/lipoyl attachment
A small domain of the E2 subunit of 2-oxo-acid dehydrogenases that is responsible for the binding of the E3 subunit. Proteins containing this domain include the branched-chain alpha-keto acid dehydrogenase complex of bacteria.hich catalyses the overall conversion of alpha-keto acids to acyl-CoA and carbon dioxide; and the E-3 binding protein of eukaryotic pyruvate dehydrogenase.
  IPR004167:E3 binding
This domain is found in the lipoamide acyltransferase component of the branched-chain alpha-keto acid dehydrogenase complex ().hich catalyses the overall conversion of alpha-keto acids to acyl-CoA and carbon dioxide . It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1).ipoamideacyltransferase (E2) and lipoamide dehydrogenase (E3). The domain is also found in the dihydrolipoamide succinyltransferase component of the 2-oxoglutarate dehydrogenase complex ().These proteins contain one to three copies of a lipoyl binding domain followed by the catalytic domain.
  IPR001078:Catalytic domain of components of various dehydrogenase complexes
The single hybrid motif has a beta-barrel sandwich hybrid fold.onsisting of a sandwich of half-barrel shaped beta-sheets. This motif is found in biotinyl/lipoyl-carrier proteins and domains.here the biotin and lipoic acid moieties act as covalently attached coenzyme cofactors in enzymes that catalyse metabolic reactions. For example.his motif can be found in the biotinyl domain of Escherichia coli acetyl-CoA carboxylase .rotein H of the glycine cleavage system in Pisum sativum .he ipoyl domain of dihydrolipoamide acetyltransferase.hich is a component of the pyruvate dehydrogenase complex .he lipoyl domain of the 2-oxoglutarate dehydrogenase complex .nd the lipoyl domain f the mitochondrial branched-chain alpha-ketoacid dehydrogenase.The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR011053:Single hybrid motif
IPR001078:2-oxoacid_dh 
Evalue:-110.05061340332 
Location:272-501IPR000089:Biotin_lipoyl 
Evalue:-21.4948501586914 
Location:57-131IPR004167:E3_binding 
Evalue:-10.7447271347046 
Location:184-220
SequencesProtein: ODPX_HUMAN (501 aa)
mRNA: NM_003477
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK00627
  Level 3 annotation:
    pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase)
  Level 2 annotation:
    Glycolysis / Gluconeogenesis
    Pyruvate metabolism
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 67 residues, 34894740-34894938Exon2: 29 residues, 34909526-34909607Exon3: 35 residues, 34925628-34925729Exon4: 68 residues, 34935506-34935706Exon5: 35 residues, 34938542-34938641Exon6: 60 residues, 34944762-34944937Exon7: 51 residues, 34948261-34948409Exon8: 21 residues, 34956246-34956305Exon9: 55 residues, 34962692-34962851Exon10: 23 residues, 34970437-34970502Exon11: 354 residues, 34973036-34974092Exon12: 2 residues, -Jump to ODPX_HUMAN  
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