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0ODO2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameDLST
DescriptionDihydrolipoyllysine-residue succinyltransferase component of 2- oxoglutarate dehydrogenase complex, mitochondrial precursor (ec 2.3.1.61) (dihydrolipoamide succinyltransferase component of 2- oxoglutarate dehydrogenase complex) (e2) (e2k).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0006091 generation of precursor metabolites and energy (TAS)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The biotin / lipoyl attachment domain has a conserved lysine residue that binds biotin or lipoicacid. Biotin plays a catalytic role in some carboxyl transfer reactions and is covalently attached.ia an amide bond.o a lysine residue in enzymes requiring this coenzyme . E2 acyltransferases have an essential cofactor.ipoic acid.hich is covalently bound via an amide linkage to a lysine group . The lipoic acid cofactor is found in a variety of proteins that include.-protein of the glycine cleavage system (GCS).ammalian and yeast pyruvate dehydrogenases and fast migrating protein (FMP) (gene acoC) from Alcaligenes eutrophus.
  IPR000089:Biotin/lipoyl attachment
This domain is found in the lipoamide acyltransferase component of the branched-chain alpha-keto acid dehydrogenase complex ().hich catalyses the overall conversion of alpha-keto acids to acyl-CoA and carbon dioxide . It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1).ipoamideacyltransferase (E2) and lipoamide dehydrogenase (E3). The domain is also found in the dihydrolipoamide succinyltransferase component of the 2-oxoglutarate dehydrogenase complex ().These proteins contain one to three copies of a lipoyl binding domain followed by the catalytic domain.
  IPR001078:Catalytic domain of components of various dehydrogenase complexes
These sequences describe the TCA cycle 2-oxoglutarate system E2 component.ihydrolipoamide succinyltransferase. It is closely related to the pyruvate dehydrogenase E2 component.ihydrolipoamide acetyltransferase. Members include the mitochondrial and Gram-negative bacterial forms. Mycobacterial candidates are highly derived.iffer in having and extra copy of the lipoyl-binding domain at the N-terminus and are generally excluded from this group of sequences as are all examples of dihydrolipoamide acetyltransferase.
  IPR006255:Dihydrolipoamide succinyltransferase
The single hybrid motif has a beta-barrel sandwich hybrid fold.onsisting of a sandwich of half-barrel shaped beta-sheets. This motif is found in biotinyl/lipoyl-carrier proteins and domains.here the biotin and lipoic acid moieties act as covalently attached coenzyme cofactors in enzymes that catalyse metabolic reactions. For example.his motif can be found in the biotinyl domain of Escherichia coli acetyl-CoA carboxylase .rotein H of the glycine cleavage system in Pisum sativum .he ipoyl domain of dihydrolipoamide acetyltransferase.hich is a component of the pyruvate dehydrogenase complex .he lipoyl domain of the 2-oxoglutarate dehydrogenase complex .nd the lipoyl domain f the mitochondrial branched-chain alpha-ketoacid dehydrogenase.The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR011053:Single hybrid motif
IPR001078:2-oxoacid_dh 
Evalue:-133.619781494141 
Location:219-451IPR000089:Biotin_lipoyl 
Evalue:-28.8239078521729 
Location:71-143
SequencesProtein: ODO2_HUMAN (453 aa)
mRNA: NM_001933
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
the generation of action potential at soma of neurons.
sdb:0313 generation of AP at soma  (Evidence:keywords)
KO assignmentK00658
  Level 3 annotation:
    2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase)
  Level 2 annotation:
    Citrate cycle (TCA cycle)
    Lysine degradation
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 34 residues, 74418371-74418472Exon2: 13 residues, 74419046-74419080Exon3: 18 residues, 74422041-74422090Exon4: 19 residues, 74425550-74425603Exon5: 27 residues, 74425730-74425805Exon6: 20 residues, 74426352-74426408Exon7: 39 residues, 74427511-74427623Exon8: 53 residues, 74429289-74429442Exon9: 27 residues, 74429803-74429880Exon10: 34 residues, 74430767-74430865Exon11: 45 residues, 74434824-74434955Exon12: 26 residues, 74436378-74436452Exon13: 30 residues, 74436744-74436828Exon14: 58 residues, 74437521-74437689Exon15: 517 residues, 74438651-74440196Exon16: 2 residues, -Jump to ODO2_HUMAN  
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Loci Cluster (Details)Loci: 2854 74815283-74818663 ~-3K 11490(FOS)(+)Loci: 2853 74418371-74440196 ~-22K 11476(DLST)(+)Link out to UCSC