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1O75148_HUMAN*   Trembl (?) | Description Local Annotation Link Reference
General Information
NameN/A
DescriptionKiaa0658 protein (fragment).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0003913 DNA photolyase activity (IEA)
0006281 DNA repair (IEA)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Deoxyribodipyrimidine photolyase (DNA photolyase) is a DNA repair enzyme. It binds to UV-damaged DNA containing pyrimidine dimers and.pon absorbing a near-UV photon (300 to 500 nm).reaks the cyclobutane ring joining the two pyrimidines of the dimer. DNA photolyase is an enzyme that requires two choromophore-cofactors for its activity: a reduced FADH2 and either 5.0-methenyltetrahydrofolate (5.0-MTFH) or an oxidized 8-hydroxy-5- deazaflavin (8-HDF) derivative (F420). The folate or deazaflavin chromophore appears to function as an antenna.hile the FADH2 chromophore is thought to be responsible for electron transfer. On the basis of sequence similarities DNA photolyases can be grouped into two classes. The first class contains enzymes from Gram-negative and Gram-positive bacteria.he halophilic archaebacteria Halobacterium halobium.ungi and plants. Class 1 enzymes bind either 5.0-MTHF (E. coli.ungi.tc.) or 8-HDF (S.griseus..halobium). Proteins containing this domain also include Arabidopsis cryptochromes 1 (CRY1) and 2 (CRY2).hich are blue light photoreceptors that mediate blue light-induced gene expression.
  IPR005101:DNA photolyase, FAD-binding
DNA photolyases are enzymes that bind to DNA containing pyrimidine dimers:on absorption of visible light.hey catalyse dimer splitting into theconstituent monomers. process called photoreactivation . This is a DNArepair mechanism.epairing mismatched pyrimidine dimers induced byexposure to ultra-violet light . The precise mechanisms involved insubstrate binding.onversion of light energy to the mechanical energyneeded to rupture the cyclobutane ring.nd subsequent release of theproduct are uncertain . Analysis of DNA lyases has revealed the presenceof an intrinsic chromophore.ll monomers containing a reduced FAD moiety.nd.n addition.ither a reduced pterin or 8-hydroxy-5-diazaflavin as asecond chromophore . Either chromophore may act as the primary photonacceptor.eak absorptions occurring in the blue region of the spectrumand in the UV-B region.t a wavelength around 290nm .This domain binds a light harvesting cofactor.
  IPR006050:DNA photolyase, N-terminal
DNA photolyases are enzymes that bind to DNA containing pyrimidine dimers:on absorption of visible light.hey catalyse dimer splitting into theconstituent monomers. process called photoreactivation . This is a DNArepair mechanism.epairing mismatched pyrimidine dimers induced byexposure to ultra-violet light . The precise mechanisms involved insubstrate binding.onversion of light energy to the mechanical energyneeded to rupture the cyclobutane ring.nd subsequent release of theproduct are uncertain . Analysis of DNA lyases has revealed the presenceof an intrinsic chromophore.ll monomers containing a reduced FAD moiety.nd.n addition.ither a reduced pterin or 8-hydroxy-5-diazaflavin as asecond chromophore . Either chromophore may act as the primary photonacceptor.eak absorptions occurring in the blue region of the spectrumand in the UV-B region.t a wavelength around 290nm .This entry represents the N-terminal part of the DNA photolyase FAD binding domain.
  IPR006051:DNA photolyase, FAD- binding N-terminal
IPR005101:FAD_binding_7 
Evalue:-142.958602905273 
Location:226-503IPR006050:DNA_photolyase 
Evalue:-76.3767471313477 
Location:18-185
SequencesProtein: O75148_HUMAN (589 aa)
mRNA: NM_021117
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentK02295
  Level 3 annotation:
    cryptochrome
  Level 2 annotation:
    Circadian rhythm
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 77 residues, 45825604-45825832Exon2: 38 residues, 45834108-45834217Exon3: 49 residues, 45836857-45837000Exon4: 63 residues, 45838974-45839159Exon5: 31 residues, 45840186-45840275Exon6: 49 residues, 45845738-45845879Exon7: 106 residues, 45847632-45847944Exon8: 52 residues, 45848179-45848331Exon9: 69 residues, 45848456-45848659Exon10: 33 residues, 45848968-45849061Exon11: 49 residues, 45850218-45850360Exon12: 779 residues, 45859040-45861372Exon13: 2 residues, -Jump to O75148_HUMAN  
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Loci Cluster (Details)Loci: 2662 45863777-45884591 ~-21K 6614(MAPK8IP1)(+)Loci: 2663 46323559-46358680 ~-35K 6625(+)Loci: 3947 46363215-46364683 ~-1K 6632(CHRM4)(-)Loci: 2661 45825604-45861372 ~-36K 6612(+)Link out to UCSC