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1O14526_HUMAN*   Trembl (?) | Description Local Annotation Link Reference
General Information
DescriptionKiaa0290 protein (fragment).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
Domain Architecture (Details)
InterPro domains assigned to SynO:
Membrane transport in eukaryotic cells is effected largely by intracellular vesicles that bud from donor membranes to transport cargo proteins selectively. One of the most thoroughly characterized budding reactions involves clathrin coats. Clathrin-coated vesicles mediate a variety of intracellular transport steps such as endocytosis.ransport of proteins from the trans-Golgi network to the endosomal/lysosomal system and budding from endosomes. Nerve terminal clathrin coats comprise clathrin.he adaptor complex AP-2 (a heterotetramer composed of alpha.eta2.u2 and sigma2 subunits) and the protein AP180. Mu2 and the core region of alpha-adaptin represent major interfaces of AP-2 with the membrane .The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR008968:Mu2 adaptin subunit (AP50) of AP2
InterPro domains unassigned to SynO:
This domain was first identified in cell division control protein 15 fromfission yeast where after the onset of mitosis.t forms a ring-like structurewhich co-localizes with the medial actin ring. It may mediate cytoskeletalrearrangements required for cytokinesis. Also occurs in protein-tyrosine it may play a rolein regulatory processes such as cell cycle control.nd in human Rho-GAPhematopoietic protein it has an inhibitory effect on stress fiberorganisation.
SequencesProtein: O14526_HUMAN (906 aa)
mRNA: NM_015122
Local Annotation
Synapse Ontology
clathrin-coat uncoating means clathrin was shed from the budding vesicle membrane.
sdb:0122 clathrin-coat uncoating  (Evidence:domains)
budding from endosome intermidate to generate fresh synaptic vesicles.
sdb:0158 budding from endosome  (Evidence:domains)
synaptic vesicles fuse with early endosomes as an intermediate sorting compartment to eliminate aged or missorted proteins.
sdb:0159 endosome fusion  (Evidence:domains)
sdb:0260 coat recruitment  (Evidence:domains)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 18 residues, 17723335-17723386Exon2: 17 residues, 17726125-17726170Exon3: 32 residues, 17726400-17726490Exon4: 26 residues, 17726926-17727000Exon5: 32 residues, 17734570-17734662Exon6: 27 residues, 17736183-17736258Exon7: 49 residues, 17738477-17738619Exon8: 53 residues, 17742233-17742386Exon9: 37 residues, 17742600-17742705Exon10: 35 residues, 17744265-17744364Exon11: 34 residues, 17744453-17744550Exon12: 17 residues, 17746047-17746092Exon13: 30 residues, 17746202-17746287Exon14: 10 residues, 17746864-17746889Exon15: 21 residues, 17747264-17747322Exon16: 61 residues, 17747791-17747970Exon17: 10 residues, 17748055-17748080Exon18: 19 residues, 17748443-17748495Exon19: 32 residues, 17749945-17750037Exon20: 94 residues, 17750417-17750693Exon21: 39 residues, 17753039-17753152Exon22: 31 residues, 17753260-17753348Exon23: 38 residues, 17753520-17753629Exon24: 54 residues, 17754825-17754981Exon25: 46 residues, 17755911-17756044Exon26: 68 residues, 17756533-17756733Exon27: 20 residues, 17758382-17758438Exon28: 57 residues, 17759490-17759655Exon29: 89 residues, 17760092-17760355Exon30: 2 residues, -Jump to O14526_HUMAN  
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Loci Cluster (Details)Loci: 4380 18168610-18175839 ~-7K 18333(RAB3A)(-)Loci: 3098 17723335-17760355 ~-37K 18312(+)Link out to UCSC