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0O10H1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionOlfactory receptor 10h1.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .
  IPR000276:Rhodopsin-like GPCR superfamily
The olfactory system is a highly-specialised chemical recognition systemthat.ike the immune system.s capable of discriminating with tremendoussensitivity between numerous foreign molecules in the environment.Olfactory transduction is believed to be initiated by the binding ofodorants to specific receptor proteins in the cilia of olfactory receptorcells. Although little is known about the precise mechanism by whichodorant binding might initiate membrane depolarisation.t is believedthat cyclic AMP may serve as an intracellular messenger for olfactorytransduction .The olfactory receptors are integral membrane proteins that belong to asuperfamily of G-protein-coupled receptors. The activating ligands of thedifferent superfamily members vary widely in structure and character.etthe proteins appear faithfully to have conserved a basic structural framework.elieved to consist of 7 transmembrane (TM) helices. Although thesequences of these proteins are very diverse.eflecting to some extentthis broad range of activating ligands.evertheless.otifs have beenidentified in the TM regions that are characteristic of virtually theentire superfamily . Amongst the exceptions are the olfactoryreceptors.hich cluster together in a subfamily that lacks significantmatches with domains 2. and 6 .
  IPR000725:Olfactory receptor
SequencesProtein: O10H1_HUMAN (318 aa)
mRNA: NM_013940
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentK04257
  Level 3 annotation:
    olfactory receptor
  Level 2 annotation:
    G-protein coupled receptors
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 320 residues, 15778890-15779847Exon2: 2 residues, -Jump to O10H1_HUMAN  
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Loci Cluster (Details)Loci: 4372 14380630-14391171 ~-11K 18171(DDX39)(-)Loci: 3093 14430110-14443670 ~-14K 18178(+)Loci: 4373 14852137-14853264 ~-1K 18201(-)Loci: 4374 14921990-14944730 ~-23K 18203(SLC1A6)(-)Loci: 4375 15325340-15351603 ~-26K 18217(AKAP8)(-)Loci: 4376 15351858-15390833 ~-39K 18218(AKAP8L)(-)Loci: 3094 15699833-15700862 ~-1K 18230(OR10H2)(+)Loci: 4377 15778890-15779847 ~-1K 18231(OR10H1)(-)Loci: 3095 16083489-16105443 ~-22K 18238(RAB8A)(+)Loci: 3096 16169730-16207156 ~-37K 18242(AP1M1)(+)Loci: 4378 16333407-16443762 ~-110K 18245(EPS15L1)(-)Loci: 4371 14119550-14177997 ~-58K 18165(LPHN1)(-)Link out to UCSC